My review of the method.

I started on an earlier version of the method, so this review is kind of a combination of the old method and the new one.

I don’t think there’s a big difference between the old and new. The older method has more emphasis on the scalp peel. I wonder whether that’s why I got such good hair regrowth in the early stages. I completed 3 peels and it totally renewed my scalp. I could see my scalp had changed like it says in the instructions. I personally think that was the turning point for me. I really recommend you pay attention to the peel. In the new version there’s much less emphasis on that, but I think that’s what made my hair start growing back.

I guess the new version is better, otherwise he wouldn’t have made it but for me the old version was amazing. And as far as I know you can’t get the old version any more.

All I would say is, use the new version but don’t skip the scalp peel. That is the most important part. However important the alteration method may seem, don’t underestimate the power of renewing your scalp skin.

I had quite naturally thick hair. It was only thinning a little in my twenties.

Then I went through a very stressful two years ago. For 6 months after that I suffered high anxiety in public. Ive got over that pretty much completely now, although I still get on edge in certain situations. This program has been an incredible help with it actually. The mind chapter alone is worth the value of the whole program. And the audio files are amazing. I listened to them twice a day for 6 months and they really changed my thinking, making me calmer again. It made a big difference to my life having something that would force me to be and stay calm all day. you can feel the difference it makes in your shoulders and neck when your muscles become loose and relaxed. I was so tense before doing this. That tension couldn’t have been doing my health
any good.

So I’d say a combination of stress and tension reduction, increased nutrient intake, the scalp renew and the alteration method are the reasons my hair grew back so fast.

This is a five star program. It’s worth the money a hundred times over.

TrustPilot Excellent

Much better than a hair transplant

Ryu befpre and after hair loss

This method is the breakthrough people are saying it is. Don’t waste your time on any other products or treatments. They can’t possibly work until you’ve completed this method. Your hair can’t grow back until you’ve healed the fibrosis in your scalp. It’s physically impossible. I completed the method a couple months back and I’m still doing parts of it daily. Once you’ve healed the fibrosis making the shininess in your scalp go away and your scalp skin looks fresh and renewed it’s just a matter of time before your hair starts going back to normal growth again.

When you complete the scalp skin reset in this method you will literally see your scalp skin return to a healthy state. My scalp was incredibly shiny, which means it was covered in fibrosis. It also means the follicles were destroyed and could never grow again on their own unless the skin was broken down and regenerated using the alternation method. Once you have reset the scalp and used the alternation method to regenerate the scalp tissue (including the follicles) the hair begins to grow back again. It’s incredible. My hair’s thicker now than it was 2 years ago. It’s still regrowing and I’ve still got a way to go but I’m on the right track thats for sure. I can see my scalp skins healed and the dormant hairs are receiving blood supply again because they’re starting to get bigger again everywhere on my scalp. First you see little blond hairs between your old hairs and along the edges of you receded hairline and then as the months pass those little blond hairs get bigger and darker as they receive more amino acids via the bloodstream. It’s an incredible method.

I’d have happily paid 100 times what I paid for the results I’ve got. I saw one fo the testimonials on the website say it’s better than a hair transplant. I completely concur. It’s much better than a hair transplant because you don’t have to go through the embarrassment of having a head covered in weird incissions for weeks! Bless you guys you’ve done a fantastic job. You deserve an award for this program.

The Advanced Hair Research Method has …

The Advanced Hair Research Method has surprised me more than I could’ve possibly imagined. I’ve been ‘studying’ hair loss for many years. I’ve been a prominent member of for 8 years (which gives you some indication of how long I’ve been trying to regrow my hair!)

In all those years I thought I’d seen every hair loss treatment and tried any that I deemed worth trying.

I’ve used Propecia, Rogaine, Lazer Therapy, supplements, retinol, Nizoral… you name it.

In all those years nothing I’ve tried has ever regrown my hair. I’ve always thought it must be possible, but never thought to try something like this.

There’s been some talk about using topical IGF-1 on HairLossTalk, but no-one has thought to use it in this way.

I started the course in June last year. The hair regrowth I’ve seen is phenomenal. It’s like nothing else I’ve seen over the years. Check out my before and afters on

TrustPilot Excellent

Thank you

Hi Chris,

I’d like to formerly thank you for taking the time to personally help my son who suffered from male pattern baldness at a very young age. He’s now 17 and looking forward to going off to college soon. His life has really turned around in the last 6 months. His confidence has bounced right back up from rock bottom. He’s back to his old self and I am over the moon to see it. You were much more of a help than you might realise. The guidance you gave him saw him through some tough times. It was really hard for him to have such advanced hair loss at his age and the difference now is amazing to see.

I knew all along he had underlying health problems but no doctor seemed to want to help. But you did. And your help has made all the difference.

I know he’s emailed you to say thank you already but I wanted to thank you myself. He’s turned his life around and I’m so happy.

Thank you

TrustPilot Excellent

Thank you Chris.

Yoshi before and after hair loss Advanced Hair Research

It’s been a year since I started the method. In fact I started on the previous version, which is very similar and moved onto the latest version around December 2016.

I would like to say thank you to Chris and anyone else involved in developing this method. You have clearly done a great job.

And to those of you who are reading this and wondering whether you should make the commitment I say you must do it. It is not a hard thing to do and the results you could see are astonishing.

Believe me when I say, if you are losing your hair, you should use this method. When I look back to one year ago and see the photo of myself then I can only say how glad I am to have made the decision to start then. If I was only just starting now I would have wasted a whole year.

It is like my hair and my skin have gone back ten years. When I look back at my old photos I look like I am sick, or I am an alcoholic or even a drug addict or something. I look so unhealthy and my hair is like an old man’s hair. I look terrible.

Then I look at my photo now and it is amazing to see the difference. It’s like a younger healthier me has been revealed and before a sick, unhealthy man was living in my place.

If you have dedication you can achieve great things. I never even conceived that I could change my life in this way but I have and I have Chris to thank. So thank you Chris. I cannot really say that enough.


I say go for it, you will not regret it

Before and after hair loss cure

I’m 62. I had very thick hair all of my life. But when I get to my 50s it began to thin on the top. By the age of 60 it was very thin, almost bald on the top. I have sent a picture into Chris so you can see my before and after. What can I say? I am delighted. My hair is not fully regrown but I am very very happy. You have to see it to believe it! As far as any downsides go I suppose it is quite a lot of effort to read all the instructions and using the Dermaroller on your scalp is not very nice. However it is not just about regrowing your hair. That of course is the main benefit but I think this is something anyone who is aging should do. It is very good for your hair, your skin and your organs. If you are thinking about giving it a go, I say go for it, you will not regret it.

Antonio Calandro

This is why I think its so effective

The AHR method is outstanding. I think I understand exactly how it works. Essentially, it’s all to do your cortisol and testosterone balance. For me high stress levels and high testosterone levels were what caused my hair to fall out so fast in my ;late twenties, I’m sure of it.

I think the reason this method is so effective is because it reduces your cortisol so much. When you combine cortoisol with testosterone you get DHT, so it stands to reason that lowering your cortisol would prevent hair loss.

What I think happens is you do the alternation method before bed, then you use the bin-aural beats. The alternation method increases IGF1, vitamin D, ECGC and antioxidants so much that causes the hormonal communication to your hair to change, so the hormones tell your hair to reactivate — just like in the example of a teenage boys face when his hormones change and they tell his dormant face hair to activate into larger darker hairs.

Because you increase the blood flow to your hair so much while your asleep and your blood contains all the hair growth nutrients it feeds the activating hairs until they are strong enough to start growing again on their own.

TrustPilot Excellent

Excited to get started

Just gained access to the method, read the first few steps and am very impressed. I can see why there are so many positive reviews. I haven’t started the program yet but I’m very impressed with what I’ve read. I’m a woman in my late fifties and I’ve tried several recommended treatments without much luck so I’m hoping this is going to work. So far everything makes a lot of sense. I’m going to start the nutrient replenishment as soon as I get back from the grocery store. I’m very excited!

TrustPilot Excellent

Thank you Advanced Hair Research

Thank you Advanced Hair Research. This method is very good. I did not imagine something so simple could have such an effect. It’s a very easy method to use, I do it every night and I don’t mind and after 6 weeks I noticed a difference in the number of hairs shed per day. I used the test every day and in the first week there was between 15 and 30 hairs shed per day and in the last 2 weeks that number dropped down to between 7 and 15 hairs per day. I am very grateful and I will keep on going every day. Thank you for all your help by email Chris, I know I asked a lot of questions. Thank you for your help!

And to everyone else I would like to recommend this method. It’s very easy to follow and very effective.

TrustPilot Excellent

Yep, it works!

I’m a man in my late 50s and I used the method for a year. I saw a cessation in my hair loss quite soon after beginning, probably just a week or so after starting. I didn’t see much else about my hair change until I finally got around to starting the Alternation Method with the Dermaroller. That I believe is the thing that separates this method from anything else I’ve tried. It works by using a Dermaroller device a few nights a week before you go to sleep. If you’ve never seen a Dermaroller, it’s a rolling pin covered in tiny needles. The needles pierce your scalp skin causing your scalp tiny micro injuries. Then you apply a mixture of ingredients that increase IGF-1 in your scalp. It takes about a minute or so to do that and I decided to do it every night even though it says to do it twice a week. While you’re sleeping your scalp heels the micro injuries and the increased IGF1 makes new hair grow.

About 2 weeks after I started the Alternation method I started seeing a whole bunch of new hairs popping up all over my scalp. And I’m not talking one or two, I mean thousands of little hairs. Then for a few months I thought I was doing something wrong because the little hairs didn’t grow much. Then I started on the isoflavones and cayenne and that seems to have kick started growth again. It’s now August (I started in November last year) and I have a whole new head of hair. It’s not as thick as it was when I was a young man by any means but it’s not bad at all. I’d like to thank you Chris for steering me in the right direction. If you hadn’t helped me out I wouldn’t have gotten such good results.

Chris I’m going to email you separately about this. I work in publishing. I have contacts at a few large publications. I’d like to help you get press coverage for your method. I think there is a lot of scepticism surrounding hair loss treatments and you’ve got something really special here. But you need help with your public relations. People need to see what this method can really do. And you need some authoritative coverage. People are always going to to be sceptical

TrustPilot Excellent

Anxiety gone. Hair Regrowing.

This thing is the real deal guys. I’ve been on the program since it first started. I was one of Chrises first Guinea pigs from the 1000 testers. If I had the foresight back then I wish I’d thought to have invested in chrises product. If it was possible to put the program into a single product I’ve no doubt it would be more popular than Rogaine one day but that’s impossible unfortunately. It’s quite a complicated method with quite a lot of different parts. That’s the main downside I guess but the upside is if you follow it every day there’s no real way of losing. I think one member (who got amazing results) said if you follow the instructions every day there’s no way you won’t regrow your hair and he’s right because the method covers every possible reason for hair loss, if you didn’t regrow your hair you either must have had a rare condition or you didn’t follow the method right. Everyone I know who followed it right got some regrowth. Some more than others but everyone got some. Mine was one of the best out of all the people I talked to, but I was young at 29 when I started and 33 now, yep time flys. Chris emailed to ask if I’d post a review so here goes…

All through my twenties I suffered from really bad social anxiety. Although I was quite healthy, ate healthy exercised, my hair just dropped out like there was no tomorrow. I was getting close to being bald by my late twenties. Chrises method covered every possible cause of my hair loss, the anxiety, the nutrient deficiencies resulting from the elevated stress hormones, the elevated DHT resulting from the elevated stress hormones. The poor scalp condition. The fibrosis. It covers everything. I started out the method in the worst possible situation and after just under a year my hair was revitalized beyond compare. It’s been a few years now and my hair is still growing, it’s slow but it’s the right direction and the change it’s made to my anxiety is just incredible. I feel 1000 times better. The hormone balancing and stress reduction have pretty much changed my life, so I want to thank you Chris. Thank you, you don’t know the difference you’ve made to my life!

TrustPilot Excellent

My hair is almost back to its full original thickness.

I’m one of the original invitees to use the method way back when it was first released. Here’s what I’ve found:

1. It does take a little while to see any results but once it starts it’s miraculous
2. I know a lot of members have seen results within a month or two of starting but I think they may have been lucky. I followed the instructions pretty rigorously and I didn’t see much change until about 6 months in.
3. When it does start to work it works wonders

The first thing you start to see is hundreds if not thousands of tiny little hairs growing around your hair line. Once you see that, providing you continue following the instructions, it’s like getting a major hair transplant. My hair doubled in thickness over the following 3 months. It really is miraculous.

Before I started the method my hair was a state of affairs. If I waited any longer I would have had to do the dreaded shave.

Now the difference is amazing. My hair is almost back to its full original thickness.

TrustPilot Excellent

If you’re wondering whether the advanced hair research method will work for you, read this.

I’m admittedly very young to have lost my hair but I was a case if extreme premature male pattern baldness. My dad is completely bald and has been as long as I can remember. I started receding at the age of 15. By 22 I had to shave my head.

Now I’m 25. I followed the method for nearly 2 years. You can’t even imagine how much of a difference it’s made. But to put it simply my hair is about the same now at 25 as it was at about 17 years old. I saw some school friends at easter and they thought I had a hair transplant. They didn’t believe me when I said I hadn’t. I didn’t know what to say. It’s kind of hard to explain that I’ve been following this strange method. So I thought it’s about time I posted a review and sent my pics in.

Chris, I can’t thank you enough. I can’t post my pics here so I’ll email them to you. Please put them up on your site so everyone can see for themselves.

TrustPilot Excellent

It seems to be working

I’m 45. My hair has been thin all over the top for years. You could clearly see my scalp all over the top so I suppose I’d lost about 75% of the hair on the top of my head. I’ve followed the Advanced Hair Research method for 6 months and I’ve seen a clear difference in the hair density on the top of my head. My scalp is less visible now and I find it possible to style my hair so that my scalp isn’t so obviously visible. Before starting the method I found d it hard to style my hair in any way that looked good because it was too thin and my shiny scalp was the only thing I’d see when I looked in the mirror! Now I’ve certainly noticed a difference in that regard. I’ve still got a long way to go but I’m glad I’m on the road to recovery. Before starting the method I had quite a lot of wispy thin hairs on the top of my head but they were too thin to make my hair look in any way dense. I believe this method has increased the thickness of the wispy hairs and perhaps even caused some entirely new hair growth. I’m going to continue with the method indefinitely. I believe it works and it isn’t hard work. The only negative I have is I don’t like using the Dermaroller! It stings. But no pain no gain I guess.

TrustPilot Excellent

Definitely Worthwhile

Even if it didn’t have any effect on my hair I would definitely use this method. But here’s what I’m seeing so far:

Individual hairs have become slightly thicker overall. They don’t break as easily and they grow faster.

Using my magnifying mirror I can see my crown bald spot has decreased in size by about a half inch.

I’ve been using the method for around 6 months.

My receding hairline hasn’t changed as yet but the rest of my hair has improved a lot, especially my crown.

I like to think I’m a scientifically minded guy and that hair loss is a condition that must be solvable if you understand the root cause. Well Chris has got it spot on with this.

I didn’t know DHT is increased due to stress. Now when I think about people I know who have lost their hair it makes a lot of sense that they are the types of guys who either get angry a lot or stressed a lot or a combination. So it also makes a lot of sense that getting your cortisol levels down to the levels that super successful people have (eg Bill Gates, Richard Branson — note they both have full heads if hair in their 60s) and superstar rockstars like mick jagger, etc it makes a lot of sense that your DHT levels will decrease and the “beauty vitamins” like biotin will increase because they’re not used up in the adrenaline/cortisol processes.

This is a great method.

TrustPilot Excellent

It’s working for me

I’m an African American male of 33 years of age. I lost most of my hair in my late twenties in the typical pattern baldness progression, with the V shape front and the thin crown. I became obsessed with finding a cure. Sounds strange saying that now, since I was never really that bothered about my hair for most of my life, but when you start to lose something you’ve always taken for granted it’s very frustrating. I almost felt there was an injustice that my hair was falling out prematurely. I was determined to somehow regrow my hair but nothing I did had any effect; even really expensive products seemed to have minimal effect.

This method is nothing like what I expected. It’s way ahead of it’s time. Compared to all other hair loss treatments this is way more advanced.

I saw some good endorsements for the method from some credible people online, so four months ago I paid for instant access and began using the methods.

I had never thought to do anything like these methods. It’s incredibly simple and very logical. The overall idea is to make your scalp condition the same as someone who has perfect hair – the hormones, the blood circulation, the nutrients, etc. It takes a few minutes to perform the main method and you do that twice a week before you go to sleep. While you sleep it causes your scalp to fill with hair growth nutrients.

My results so far are not at all what I expected. I thought that my hair might get a bit thicker if I was incredibly lucky; in fact what I’ve seen is hundreds and hundreds of new little hairs growing up around the edges of my receded hair line. My hairline looks as though it’s slowly regrowing. It takes time but it works. My crown area also feels a little thicker. I haven’t properly checked (it’s difficult to do so) but I’m certain there are new hairs growing in my crown area too.
The method is easy to use and very effective. If you’re used to seeing the kind of results you get from mainstream hair lsos treatments you’ll be shocked at the results you get from this method.

TrustPilot Excellent

Truly Amazing. My hair hasn’t been this healthy for over ten years….

I’ve been using the Advanced Hair Research method over the last year to make my hair grow longer. I’m a woman in my early thirties. My hair wouldn’t grow past my shoulders due to damage caused by years of peroxide use and probably due to stress.

Chris sent me a copy of the instructions to trial for use in growing longer hair (I’m a blogger so I’m reviewing the method for my blog and I’m sending my pictures to Chris to post on his website).

The change has been nothing less than miraculous and I can’t wait to post my full review with pictures to my blog but I wanted to get this review posted first to let you guys know about this.

My hair used to be really long (when I was a teenager). It was also thicker, healthier and naturally beautifully shiny. During my twenties I got my roots done every month, or every other month at times for ten years. By my late twenties my hair would barely grow and it was incredibly unhealthy – frizzy, broken and in horrible condition.

I’m still getting my roots done. My hair grows so fast though now I have to get my roots done more often. This method has saved my hair. The difference it’s made has been extraordinary.

Please check out my before and after pictures on Chris’ site to see what I mean! This method has added an extra 5 inches of length to my hair! My hair hasn’t been this long for well over ten years. It’s truly unbelievable. My hair is also less damaged (less split ends) and it’s thickening up at the roots.

It’s amazing. I’d never thought of doing something like this to make my hair grow longer. Chris’ method is amazing. I whole-heartedly recommend it to you guys.

TrustPilot Excellent

Not only has my hair density increased …

Not only has my hair density increased significantly, my hair has also improved greatly in texture and the colour is even coming back! I’m gobsmacked by how my hair is changing. I couldn’t have imagined this method would have been this effective. It’s really remarkable.

Link to my before and after pics uploaded here:

imgur .com/a/7ETaJ

I actually bought the program almost just out of curiosity to see what all the fuss is about and decided to give it a go. 6 months down the line and here I am. It’s better than I could’ve possibly imagined.

The difference I feel in my self is really amazing. I feel like a thousand bucks, as they say. The transformation is more than just in the appearance of my hair. It’s the feeling I get every time I look in the mirror every morning and I feel 10, or even 20 years younger!

I really can’t thank Chris enough. It’s like a whole new lease of life.

If you’re thinking about using Chris’ method, stop thinking and get on with it! It’s the best decision I’ve made in a long long time.

TrustPilot Excellent

Seeing Hundreds of Reactivated Follicles

I started the program in December last year. I’ve completed steps 1 – 4 and plan to complete the cleanse next spring but I’m not too fussed about that because I’m already getting really good results.

I can see a whole line of reactivated hair follicles at the edge of my hair at the front. They’re just starting to become full color and most of them are about 1 to 2 inches in length.

I first saw them about 2 months after starting the program but I thought they were old hairs and didn’t think much of them. Since then they’ve grown to about 4 times the size and there are about 200 of them at the front of my scalp. It’s astonishing to see so many new hairs growing.

I can also see them along my parting sticking up. Some of the hairs further back have grown to around 3 inches in length.

I’d 100% recommend the program. It’s only been 6 months and I’m really happy with the results.

TrustPilot Excellent

My hair is much thicker

Glad to hear you’ve got reviews set up at last Chris! I’ve wanted to post one for a while.

First of all I want to say thank you. It took me some time but at last I am seeing the new hairs on my scalp. It’s been something like 8 months I would say. And I noticed straight away that my hair loss had at least slowed down but I didn’t see too much else for months and months. I was starting to think it might not work. I contacted Chris and he was quite slow to reply but eventually hey he does exist! Just joking Chris I know he will read this! Chris gave me a few pointers, which was very helpful. I wasn’t doing the scalp exfoliation at all so I started doing that 4 times a day to kind of catch up a bit. Then maybe 6 weeks later I saw a hair in my receding hair line and I thought, what is this? I hav enever seen this hair before! Where did it come from? I was laughing to myself in the mirror. It was very strange because it is about 1cm away from my receded hairline. After a couple more weeks I saw two more of these small hairs (both on the same side of my head strangely). Probably around a month later I saw one one the other side and then I looked very closely at the front of my scalp and I noticed there were absolutely hundreds of them in between my hairs! I thought my hair was looking better. Like it was easier to make it look good when I waxed it in the morning but I had not realised that the method had started working. It’s been about 8 months now and I am very happy. I did not really think something like this would work.

TrustPilot Excellent

My hair is visibly thicker..

I used their method for around 6 months. I’m actually stunned by how well it’s worked. My hair wasn’t super thin before I started but it was thin for my age and it bothered me. It was bothering me more and more. Every time I washed the wax out of my hair I’d see like 20 hairs, which scared me every time, making me think I’d go completely bald in a few years.

I was fairly strict and stuck to the regime well, drinking the smoothies every morning and completing the scalp reset carefully. I did the exfoliation every day and the alternation method 3 times a week. I cheated on a few things but mostly I stuck to the guidelines.

Within 3 months my hair was almost back to how it was when I was a teenager. And I’m not exaggerating. I checked out my photos on Facebook and in my latest ones from the last few weeks I look younger than I did 10 years ago! And it’s all down to my hair. I used to have to style my hair over to the side to hide how thin it was and now I can style it spiky again like I used to when I was younger and I look like 10 years younger. It’s incredible the difference thick hair makes.

I’m continuing to use the method even though my hair is almost back to full thickness. I want to get it as healthy as possible. And following this regime has made my skin a lot healthier. I don’t get any spots now (I used to also suffer from some mild adult acne). I would definitely recommend it. It’s worked for me.

TrustPilot Excellent

I cannot believe mow much my hair is regrowing

I cannot believe mow much my hair is regrowing. This method is extremely effective. I did not expect it to be as good as this I must admit. To describe what is happening, my hair is very thin on the top and normal thickness on the sides and the back.
I used to be able to see my scalp very clearly through the hairs because they were very sparse. Now there is like a new layer of hairs which are shorter than the other hairs.
I have my hair spiked up. Usually I would see my scalp, which used to be very greasy. My hair was so thin that I could see my entire scalp. Now, there are hairs all over my scalp where it used to be bald. My scalp is no longer greasy, its healthy looking. The new hairs are at least 4 times more numerous than the old hairs.
If you’re just starting out don’t get overwhelmed. At first I was quite negative about the method. I didn’t think it would work, but it does. You just have to keep going and be a be patient. It all makes sense and it’s all based on good research, it just takes a little time.

TrustPilot Excellent

It’s definitely working for me

It’s definitely working for me. I’m seeing the same thing as everyone else. Between my old hairs there are millions of thin blond hairs. It’s kinda like a carpet of hairs all in between the old hairs. The old hair on the top of my head is really thin. There is about 4 or 5 milimetres between each of the old hairs at the front. Now, in between each of the old large hairs there are around 50 to 100 new blond hairs within the space of 4-5mm. They haven’t been there for long. Maybe a few weeks. I hadn’t noticed that they are all throughout the spaces between the big hairs before yesterday.

I didn’t really notice them until yesterday and now they’re about 2cm long (about an inch). They’re very thin. But there must be thousands of them because I can see hundreds just in the first few cms of my scalp. My old hair is a lot thicker after about 3cm back from my hairline so it’s harder to see in between the old hairs.

I’ve been using the method daily for about 9 weeks now. I follow it very carefully and do the boar brushing 4 or 5 times a day. Sometimes even more. The most annoying part for me is the smoothies. Everything else is easy. The smoothies are a hassle for me but I’m not going to stop drinking them because I think every part of the method is important and I don’t want to risk messing anything up now that it’s working so well for me.

I don’t use any other hair loss products or treatments so I can confirm that this method does work.

I am male, 28 and have been losing my hair very gradually since I was 21 to give you some context.

TrustPilot Excellent

Young Hair Loss

I’m very young, only 19. I’ve suffered from horrific hair loss from a very young age (14 or 15), which has verged on ruining my whole life. I stopped going out as much, I always wore hats. I was always worried to be in well lit rooms or outside in the sun because people would see my horrible sniny scalp. I was amazingly shy around girls. I tried my best to stlye my hair forward and spiky to hide the thinness but what girl would want a 19 year old guy who looks like hes got cancer or something.

I went to three differnt doctors about it and they all said the same thing. They basically tell you there’s nothing you can do, except they say it with tonnes or complicated words. I was prescribed Propecia, which I took from ages 16-18, which is very young to use it but the doctor said in my case it’s worth a shot for a short while because I was so depressed. This really helped for about 6 months and probably saved my hair a bit but then it stopped working and I started noticing the side effects. Not only was I shy around girls, now I had no desire to be with a girl at all. It was like I wasn’t a man, I was just a thing. A pointless person, just existing. I became amazingly depressed, I had to take depression medication. Then one day I was reading Chris’ blog and I looked at my life and realized this one single stupid horrible thing was ruining my whole life. I couldn’t do anything I wantde to do. It was terrible. So I stopped taking Propecia and vowed never to take it again. I downloaded Chris’ method and I read it. After reading that my mind was changed. I felt a lot better because I knew I could do something about my life. I had the power to fix my problems. And it was all there for me, I just had to do it.

I wqas pretty determined to succeed after the terrible year I’d been through. I’ve had some major bad luck in my teens but I’ve got a lot of determoination when it comes down to it. I stayed committed to the method for a whole year. My hair started growing back about 6 months ago and from there onwards its got better every week. I didn’t bother to count hairs or anything like some guys did. I didn’t need to cos my hair was regrowing so quick. Now it’s nearly fully back to normal like when i was 13.

I’m a thousand times more confident now and I’ve even got a girlfriend. Its like I was postponing everything in my life and now I’ve sorted it I’m starting again and I’m so happy.

I’m just happy I finally fixed it. I wish I had found Chrises website when I was 14.

TrustPilot Excellent

The method works. Make sure you do it like this though…

You guys might know me from the forums. I’m Topper. I wanted to post a review here 1) to tell you all my success story and 2) to give any newbies some tips about what to concentrate your time on.

I had standard genetic male pattern hair loss with diffuse thinning on the top of my scalp. Some of it was caused by stress, but 80% was caused by androgen hormones.

So here’s how I’m doing:

– 3 months ago I saw the first reactivated hair folllicles
– Today I estimate I’ve reactivated 1500 follicles
– Based on progress so far I predict I’ll reactivate all remaining dormant hair follicles within 6 months

My hair is already much thicker and I think it will return to full thickness and health within 6 months.

Here’s how I did it

(throughout all of this I continued with step 1. Don’t stop step 1)

If you have genetic hair loss, use the isoflavones, cayenne and green tea every day. This is just a recommendation in the instructions but I think this is ESSENTIAL.

What most people don’t know is genetic hair loss is kick-started by stress (cortisol hormone) as you all will read in step 3. So more cortisol = more DHT.

Don’t skip the stress step. At first I skipped this step because I didn’t think it would have a great effect. There’s a reason Chris included this step. Bringing your cortisol hormone right down before going to sleep and when you wake up is absolutely key to this method. Testosterone + cortisol = DHT.

Testosterone is highest in the morning, so you need to get your cortisol down as low as possible before you go to sleep. Otherwise your DHT will be really high in the morning.

Using the mp3s before you go to sleep is also why you sleep so well (which is what a lot of you all members say). Sleep is when your cells regenerate and your cortisol hormone drops. That’s another reason deep sleep is important in the method. Use the binaural beats that you download in the members page. Don’t skip that whatever you do! You can use the silent subliminal version if you don’t want to hear it but I like the binaural version cos it relaxed my muscles. Having low cortisol before sleep is life changing. It makes everything in your life better.

I wanted to mention all this because as soon as I started step 3 I saw the reactivated hair follicles start to show.

If you have genetic hair loss or stress related hair loss reducing cortisol is one of the most important parts.

Good luck everyone. Stick with the instructions closely. And remember cortisol is more important than you might think. Even if you don’t think you’re that stressed.

It works. Just stay with it and you will regrow your hair.

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MY STORY: How this method changed my life

I’m a 25 year old male with premature male pattern baldness. My hairline has receded and the hair on the top of my head had become very thin. A year ago I became depressed, even experienced social anxiety. I started to get insecure about my appearance, I became very shy, didn’t want to approach women. I started getting really self conscious about my hair. It seems kind of strange now but I was obsessed. My hair used to be real thick and real good. It kinda made me good looking.

My confidence had totally drained away and I realized that girls really do care about looks. Believe me. My mum told me don’t worry about your hair, girls don’t care about that. Believe me they do.

I decided I had to do something about it otherwise I’d end up in my late twenties, bald, single and lacking any confidence to change my life. At the time I was researching on the internet a lot about hair loss and I found Advanced Hair Research. I bought access and started following the method.

2 months later my hair started getting thicker. It wasn’t just a small amount either. It was getting much thicker. Within 6 months my hair was starting to look awesome. Now, a year later it looks better than it’s ever looked. And believe me it’s made such a difference. I’m a thousand times more confident now because every time I look in the mirror I feel good. Every time I get ready to go out I feel good. I feel good when I brush my hand through my hair.

I realised that all this adds up. Whereas before every time I looked in the mirror it made me depressed, now it’s the complete reverse. Imagine, you look in the mirror like 10 times a day. That’s 300 times a month, 3650 times a year. So all those times I was looking in the mirror and getting such a downer. It ruined my confidence. It ruined my life.

Now I have the total opposite. Every time I look in the mirror it boosts my confidence. It all adds up. I realize now how important this is. This is the real reason why girls like good looking guys. Not because they’re good looking. Because they’re so confident. Now that I’m so much more confident girls notice it.

I remember when I felt so down all the time. My life was crap. This method has turned my life around. In more ways than just my hair and my confidence. The hormone balancing makes you feel so much better. It’s like my life was completely messed up before cos my hormones were out of balance and they made me depressed, made my skin bad and made my hair thin. Now that I’ve fixed my hormonal balance everything has turned around.

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It works.

This method is very very clever. I can’t see how anyone’s hair wouldn’t regrow if they follow these instructions. Basically it works by making your scalp hormones the same as they were when you were young. So you apply this mixture of ingredients to your scalp and you drink a smoothie and gradually over a number of weeks your scalp hormones change. This is basically the reason most people go bald – Because they have a build up of DHT hormone in their scalp and very low IGF1 and IGF1 is what basically makes your hair grow. So when you use this method after a while the hormone levels in your scalp start to go back to how they were when you were younger when your hair was growing thick.

I used the method for 6 months almost every day. I did it as much as I could cos I wanted to get my hair back as fast as possible. My hair is buzzed so any change was instantly visible. As soon as I started doing step 3 I was buzzing my hair TWICE AS OFTEN!!!

By about 5 months I stopped using the method cos my hair was just about as thick as I need it. I’ve been recommending Advanced Hair Research to everyone I know who’s losing their hair. I should get a referral fee!

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Female with Andogenic Alopecia. AMAZING Results so far

I woke up this morning had a shower looked in the mirror like I always do. Then I looked up close at my scalp and saw these new little blond hairs in between my dark hairs. I carried on looking and I realized my scalp was covered in them!!! I couldn’t believe it. One of them is already quite long and at least 15 of them are growing infront of my receded hairline, which means my receded hairline is growing back! I’m amazed at how effective the AHR method is. I’m so thank full.

I’ve wanted to regrow my hair for a long time but couldn’t justify the expence of a hair transplant. I was starting to seriously think about getting one But this is far better. I think there must be thousands of new hairs on my scalp. My old dark hairs are all still there but now there is a much thicker layer of smaller blond hairs. They’re not full grown like the darker hairs. They’re kind of transparent-blond and thin. But there are absolutely thousands of them. My hair used to be very thick, so I think once these hairs grow to full size it’ll will be very thick again.

This method is very powerful. I 100% recommend it.

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Honestly didn’t think it would be this effective

I’m male, 32, been trying to regrow my hair for nearly 10 years with very limited success. Started the ahr method 6 months ago. Completely blown away by the results. I honestly didn’t think it would be this effective. My hair’s almost twice as thick now, close to how it was in my early twenties. It grows very fast. I can actually style it properly for the first time in years. I also feel 10 x better. The massive intake of nutrients every day makes you feel awesome. I feel healthier now than I’ve ever felt.

I’d recommend to anyone to do this. Even if you’re not losing your hair. The method improves the health of your whole body. By sorting out your hormones so they’re in the best balance everything else gets a thousand times better. Your hair, your skin, your energy, your sleep, your focus. Everything.

To anyone out there thinking about it. If you want to regrow your hair and get much more, do this method.

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Thank you all SO MUCH!!!!

I’ve had problems with my hair for at least ten years. I think the problems stem from stress. I’ve had a stressful life and it effects the way I eat and sleep and it makes me very tense. I never actually lost my hair, it was just thinner than I wanted it to be and it grew very slowly and it was damaged. I dye my hair blonde and have done for over ten years. My hair was very weak and broke easily so I had to get my hair cut regularly to stop it from looking really frizzy. After a while I had to cut my hair so short it just looked un feminine and I hated it. My hair was so broken that I couldn’t grow it long because it would break after it grew a few inches, which made me even more stressed and obsessed with my hair.

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It’s already starting to work

It definitely works. It’s only been 6 weeks but I can already see new hair growing all over the top of my head. I followed the method closely for the last 6 weeks and it’s already working extremely well. I’m on step 4 and I’ll start step 5 soon but I don’t think I’ll need to complete the rest. I’m only 25 so I was lucky enough to start the method before my hair loss got really bad. If you stop it early that’s your best chance if reversing hair loss.

My only feedback for improvement of the method instructions would be for them to sell the items you need in a package. That would be much better if you could buy everything at once and start straight away. Having to read it and then buy the items takes time. I think they should sell it all as a package.

Other than that I am over the moon with how it’s all worked out. Nothing is more effective.

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Highly recommend

When I was asked to test and review the Advanced Hair Research method a year ago I had several doubts about its legitimacy. A year later, my doubts have been completely eradicated. So much so in fact that I am more than happy to sing the deserved praises of this method.

The creator, Chris Carter, deserves great respect for single-handedly developing a system so effective and yet so simple to follow. His method is quite simply extraordinary.

I consider myself to be a critical thinking, perhaps even cynical man and the notion that a programme like this could have such an impact on my life was wholly unexpected.

The method, in essence, restores the scalp to the condition it was in before hair loss began so that no further hair loss occurs.

From what I gather, hair loss is caused by an androgen hormone called DHT. DHT causes hairs to miniaturize over several years until they become dormant. In other words, they no longer grow.

This method essentially sends a chemical message to the dormant hairs, telling them to regenerate into full-size hairs. It seems that hormones are both the cause of hair loss and the reason for hair growth and therefore having the right hormones in your scalp is the basis of this method and by the looks of it, it works incredibly well.

After following the programme for a month I started noticing small blonde hairs cropping up sporadically around my scalp. Within one more month there were at least 100 of these newly reactivated hairs appearing in various positions around my scalp. Whether my experience is typical, I can’t say but judging by the reviews it seems my experience is reasonably standard.

For these reasons and much more I highly recommend this method.

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I really wasn’t sure about the “AdvancedHairResearch” method. I decided to do some digging and I looked into the author Chris Carter to see if I could find out anything about him. There isn’t much, but I found some scientific journals he’s contributed to that have been published online and a few other things that would indicate he’s genuine and has some credibility in the field – although its so hard to tell on the internet. Quite frankly it just seemed implausible to me that some hair loss researcher from London has found the cure for hair loss.

Curiosity got the better of me and I paid to access his program. I gave it a read and in fairness it’s impressive. One thing I have to give him credit for is his vigorous referencing. Nothing would have irritated me more than to have found he’d re-written a load of stuff from the internet. His method is actually not bad. I’ve incorporated several of the method’s elements into my daily regime. I was particularly impressed with the Alternation Method, which I consider to be a superb idea and not something I had thought of. Whether I will see any results is yet to be seen, but based on what I’ve read so far its a lot better than I expected and certainly worth a try. Based on the other reviews it looks like it will take some time before I see any new hair growth but I’m going to give it a go.

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I would recommend them without doubt

I’m really surprised by the Advanced Hair Research Method. It’s genuinely a very intelligent and sophisticated means of reversing hair loss. Since hair growth is controlled by hormones, by making the hormone levels in the scalp more like those in a youthful, healthy scalp, it’s logical that hair should begin to grow again. In simple terms, according to the literature, scalp hair stops growing when subjected to the androgen hormone DHT. Whereas face and body hair ‘activates’ to become thicker and longer when subjected to DHT. The author, Chris Carter, has simply taken the action that causes face and body hair growth in men and used it on the scalp to cause dormant hair follicles to reactivate. However, dormant scalp hair follicles require different hormonal triggers to reactivate.

The programme leads the user through a process of gradually improving the hormonal balance in the scalp until it resembles that of a youthful, healthy scalp. Then, by a system of mildly damaging the scalp using a Dermaroller and then introducing increased IGF-1 (a growth factor), the dormant hair follicles begin to reactivate, just like the dormant hairs on a teenage boys face activate when he goes into puberty. The logic of the method is undeniably well thought through.

My hair regrowth

I suffer from standard male pattern baldness. Only 12 months ago I had a clearly visible bald patch in the crown of my hair. Over the course of 12 months new hairs began to grow in the bald patch. Now the crown of my hair is once again filled with hair. It is not yet at full thickness but compared with 12 months ago the difference is more than impressive. In fact, impressive is the word I’d use to describe Carter’s method in every way. It is without a doubt something I would recommend to anyone suffering from male patern baldness. The logic is sound, the method is simple to follow, it’s very cheap and it’s decidedly more effective than any other treatment I have tried.

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If you follow it correctly you will regrow your hair

I’m a 27 year old male with standard male pattern baldness. I started using the AHR method 2 years ago (I was an invitee in the first phase). I didn’t reactivate my formant hair follicles fo rthe first year, then I made a few changes and my hair started growing back rapidly. Now my hair is pertty much as thick as it was when I was 21.

If you’re following this method please make sure you do the scalp reset and daily exfoliation. This is especially true if you’re a man who’s used a lot of hair gels/waxes/etc. Just imagine for a minute how many years you’ve used hair gels and then gone to sleep with the gel still in your hair. That gelor wax or whatever then gets mashed into your scalp while you sleep.

I didn’t think anything of this until I saw some of the other members mentioning that they got no hair regrowth until they did the daily exfoliation and then suddenly everything came together and their hair grew back rapidly. The exact same thing happened to me. My hair loss slowed down and maybe even stopped but I didn’t see any of the new baby hairs everyone talks about. Then I started doing the exfoliation techniques every day and literally a month later I saw the little blond baby hairs. Hundreds of them. Maybe even thousands.

Basically by following the exfoliation method every day you get rid of all the dead skin cells, gels and sebum that have built up and filled the pores in your scalp where there hairs are supposed to grow. It takes some time to break this layer of build-up down but it works. And because you’re invigorating your scalp so much all the amino acids and hair growth nutrients you get from the smoothies flood into your scalp and feed the new hairs. Then you add to that the IGF1 increase and the Alternation Method and hey presto, it works.

So make sure you do the exfoliation. Don’t make my mistake.

This method is pure genius. If you follow it correctly you will regrow your hair.

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This is the future of the hair loss industry.

I was only 21 when I noticed my hair was falling out more than usual. I saw the front of my hair had receded in V shape and the top along the the center of my hair was thinner than when I was younger by about 1/2.

I used a whole load of hair loss treatments including Fabao topicals, Kirkland Minoxidil, Spectral topicals, Propecia, Nourkrin, MagniGro and even some eBooks I downloaded from the internet. I need to make something clear to anyone reading this. I’m 27 now. I’ve tried pretty much every hair loss treatment that you can get and I don’t understand what is going on in the hair loss industry today. Why are there so many treatments available today that seem to really do nothing? I seem to have tried them all so I guess I’m pretty qualified to tell you none of these treatments seem to work. Hey maybe they work for some lucky people? Not for me though.

I continued my search for a treatment for 6 years until one day I came across some research from a guy called Chris Carter who wrote an article online about hair loss and it really rang true with my experience. And that is that taking a supplement or using a lotion will never stop your hair loss. And that the closest thing toa treatment that works is Propecia (a prescrption drug). And what does Propecia do? It changes your hormonal balance. So for the first time I realized what I think should have been obvious to me all along, that there’s a powerful underlying cause of hair loss and it’s not something that an off the shelf treatment is going to have any effect on. The reason all the reviews of Chris Carter’s method are so good is because it does something that no off the shel treatmenmt can do, it treats the underlying hormonal imbalance that sets in motion a snowball effect of problems in your body that essentially leads to fibrosis in your scalp, which ultimately is what causes hair loss.

So it seems like the best way to actually treat it is to firstly fix the underlying hormonal imbalance and then systemmatically eliminate each of the knock-on effects that result from that root cause – the excess sebum, the fibrosis, etc.

I really think there needs to be a change in the hair loss industry. Why is that products like Fabao 101 and Nourkrin get masses of attention, yet they seem to get zero results? Not some results. No results at all. Yet there’s this guy Chris Carter who’s made a method that’s geting only positive reviews (and the reviews that are published must account for a small percentage of overall feedback), and this method seems to get no attention? Chris you need to find some marketing guru to help you, otherwise some big business is going to steel this from you I guarantee it. This method is unlike any other hair loss treatment.

People, please stop wasting your money on over the counter products.

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I Still Can’t Beleive it.

I used to have very thick awesome hair, it was like my trademark, or what made me good looking. I ate really badly, smoked, drank a lot and did quite a lot of drugs in my younger years and I thought that must have been the cause but then I quit all drugs, quit smoking, cut down my drinking to healthy amounts and starting eating a healthy diet. Still my hair loss was getting worse, even worse than before. So I was stuck, I didn’t know what to do.

I signed up for an invitation to get the Advanced Hair Research Method before it was released.. It was slow progress at first, in fact for the first 6 months I didn’t see a great deal of change. My hair loss stopped after only a few weeks of using the method but I didn’t see any new hair growth and I was worried that it was too late for me, but i kept on using the method anyway. It didn’t bother me because it only takes a few minutes and at the every least you feel like you’re doing something positive. I was reading all the posts in the forums and seeing loads of people who had regrown their hair and I couldn’t understand why it wasn’t working for me.

Then a month ago I saw a post from someone who was using the scalp exfoliation twice a day instead of once and getting amazing results. It was a woman but the hair regrowth was crazy. So I decided to concentrate more on that. It takes like one minute per day so I was fine with it.

Then, guess what, just two weeks later i saw the same thing everyone else was talking about: new little hairs all in between my old hairs.

I think the trick is you have to try all the methods in the instructions because there might be one thing that’s blocking your hair growth that you need to remove. The one thing I missed was the one thing I needed to do.

The method is really good. It takes you through a very simple step-by-step process of eliminating anything that can prevent hair growth – DHT, scalp fibrosis, a nutrient deficiency, excessive sebum in the scalp, blocked scalp pores, stress, low co-enzyme A, and way more. Some people are lucky they can do the two main things, the IGF-1 and the smoothie and that’s all they need.

All I can say is don’t skip a step! Do them a;l until you see hair regrowth. And just keep on going. Don’t give up. I came so close to giving up and being a baldy for the rest of my life. I’m so damn glad I fixed it in the end. But I think I was lucky, or I was not wiling to give up. I think you have to be quite determined to use this method. But its worth it big time.

Good luck folks! Don’t give up. If it’s not working just email Chris, he’s pretty slow at getting back but he does eventually 😉 !!! Thanks Chris you’re the man.

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This method works

This method works. I’ve been using the method almost everyday for 3 months. I was very lucky and saw the new baby hairs starting the emerge after only one month. I can’t explain the feeling you get when you see that. It’s been extremely hard for me losing my hair because I’m very young and my hair has always been a big part of my identity. When my hair started getting thin I became much much worse looking. As a young man in my early twenties it was pretty devestating to start looking unhealthy and ugly. When you start losing your hair at such a young age I think people presume there’s something wrong with you. Like you’ve got cancer or something.

So you can imagine when I saw that my hair was starting to get thicker so soon after starting the method I felt like a million bucks. My confidence is coming back, I have a spring in my step when I leave the house. I feel confident talking to people when there’s a strong light above my head.

Every week I give me scalp a good inspection and every week I feel better. I get a real buzz out of seeing more new hairs.

I don’t want to post my pictures up online because I’m too embarressed and I’m not using my real name in this review but I wanted you all to know you don’t have to suffer like I did. 3 months has passed and I estimate that I must have grown about 1500 new hairs. I base this on my count of roughly 50 new hairs at the top of my forehead in an area about 1 inch. Multiply that by about 30 square inches on the top of my head and you get 1500 new hairs as a rough estimate.

There’s a better way of counting the number of hairs somewhere in the instructions, but I can’t find it.

Anyway I’m pretty happy with roughly 1500 new hairs in 3 months. Even if it was just 500 I’d be pretty happy! I’d of been happy with anything 3 months ago. Now my aim is to get 3000 more new hairs by Christmas time. I think its possible.

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Phytosterols for Hair Loss: How and Why You Should Use them

Phytosterols are compounds found in plants, also known as sterols and stanols, structurally related to cholesterol. There are over 200 types of phytosterols available but the most common phytosterols are β-sitosterol, campesterol and stigmasterol. The idea that phytosterols are effective in the treatment of hair loss has been proposed after scientists discovered their benefits in skincare products.

Phytosterols work in the body by mimicking chrolesterol and preventing the depletion of epidermal keratinocyte membranes, which means that they basically reduce damage from aging processes on the hair and skin. Their main use is in anti-aging products, moisturizing products and wound healing products but more and more companies are developing products based on plant phytosterols that may help with hair loss.

How do Phytosterols reduce hair loss?

Reduction of scalp inflammation

There are several reasons that may explain why phytosterols can be helpful in the treatment of hair loss. One of their main characteristics is their anti-inflammatory potential. Inflammation is often one of the characteristics of the alopecic scalp and several studies have shown that phytosterols have great anti-inflammatory purposes (Aldini et al., 2014)(Othman and Moghadasian, 2011)(Rocha et al.,2016) In vitro studies showed an inhibition of the inflammatory markers such as interleukin-6 (IL-6) ) (Trautwein and Demonty,2007). Their topical anti-inflammatory effects in both acute and chronic inflammatory models have also been demonstrated (Garcia et al.,1999), for example their anti-inflammatory and anti-fungal effects on skin disease like seborrheic dermatitis which would explain their potential to reduce inflammation of the scalp.

Reducing DHT

Hair Growth Cayenne and Saw Palmetto Shampoo
Shampoo containing cayenne and saw palmetto

Another way phytosterols seem to reduce hair loss and increase hair growth is their reduction of 5-alpha reductase — the enzyme that converts testosterone into DHT. (Liang and Liao, 1995;1997)(Delos et al.,1997)

Plants containing phytosterols, which have been studied for their inhibitory effect of 5-alpha reductase are saw palmetto, sesame seeds and argan oil. In-vitro studies suggested that topical solutions made with these plants showed significant inhibition of 5-alpha reductase in the skin which makes a strong case for phytosterols as DHT blockers.

the participants receiving pumpkin seed oil had a hair count increase of 40%

Pumpkin seed oil was also researched as a 5-alpha reductase inhibitor and has been shown to have anti-androgen effects on rats. In the same study 76 male patients suffering from androgenetic alopecia received 400mg of pumpkin seed oil or a placebo for 24 weeks. The change over time was evaluated and the participants receiving pumpkin seed oil had a hair count increase of 40%. The results could be due to essential fatty acids and phytosterols as both have an inhibitory effect on 5-alpha reductase. (Cho et al., 2014)

Topical saw palmetto and minoxidil serum

Serenoa repens, also known as saw palmetto, is another plant containing fatty acids and phytosterols that benefit the hair and scalp, not to mention the fact that it has been used for centuries as a treatment for hair loss. A study (Fasculo, 2004) used shampoo and topical lotion containing serenoa repens as a treatment for balding participants. The treatment had to be followed for three months. The results showed an increase of 35% in hair density and 67% increase in sebum reduction.

Best ketoconazole shampoo

Topical ketoconazole is often prescribed to male pattern baldness patients in order to reduce DHT and inflammation in the scalp. Tosti A. (2006) showed that adding just 0.5% extract of saw palmetto to a ketoconazole shampoo increases the effects of the ketoconazole substance on the scalp significantly.

One of the large components of phytosterols is beta-sitosterols, which may be responsible for reversing hair loss due to their inhibitory effect of 5-alpha reductase enzyme. A study in 2002 (Prager et al.) evaluated certain botanical compounds that had the same effect on 5-alpha reductase as drugs and agents used to treat benign prostatic hyperplasia. Benign prostatic hyperplasia patients are similar to people suffering from hair loss in the sense that in both cases their DHT levels are increased and sometimes finasteride is prescribed to both to reduce DHT. The researchers used liposterolic extract from saw palmetto and beta sitosterol as treatment for androgenetic alopecia on males between the ages of 23 and 64. The results showed that 60% of the subjects had significant improvements during their final visit and researchers concluded that beta sitosterols and liposterolic extract of saw palmetto were effective as natural 5-alpha reductase inhibitors.


Phytosterols contained by various extracts and oils are also known for their antioxidant effects and this could also contribute to their effect on hair health. (Yoshida and Niki, 2003) The theory that hair falls due to oxidative stress was proposed as early as the 1950s. Free radicals are thought to damage hair either through the body’s metabolism or externally from the environment and with age the body’s mechanism to fight ageing decreases. (Trueb, 2009)

mice treated with lavender oil had significant hair growth compared to the control groups

The authors concluded that the peppermint oil induces a rapid anagen stage

Lavender Oil, another rich source of phytosterols is known for its benefits in the treatment of hair loss. A study on mice showed that mice treated with lavender oil had significant hair growth compared to the control groups concluding that this oil could be used as a hair growth promoting agent. (Lee et al., 2016)

Peppermint Oil seems to have similar benefits to hair as it was shown in a 2014 study (Kim et al.) where mice treated with the oil showed prominent hair growth, significant increase of dermal thickness (a decrease in thickness is often associated with androgenic alopecia), increase in follicle number and greater follicle depth. The authors concluded that the peppermint oil induces a rapid anagen stage and can be used as a treatment for hair loss with few to no side effects.

Besides applying phytosterol containing lotions on the scalp, a phytosterol rich diet may also contribute to the health of the hair from within. Phytosterols can be found in plants, especially in wheat, nuts, rice and soy. A diet rich in phytosterols can contribute to better blood circulation, which may inadvertently help with hair loss.

Phytosterol supplement

A number of studies have demonstrated the effectiveness of phytosterols in treatment of androgenic alopecia (AGA). In these studies, the extracts of fruit of the saw palmetto (Serenoia repens) or pumpkin seed oil (PSO) were used as they have a high content of phytosterols (Woelfle, 2010; Cho et al, 2014).

Prager et al (2002) conducted a study on healthy males aged 23-64 years with mild to moderate AGA to investigate the benefit of an extract of saw palmetto and β-sitosterol in treatment of the condition. At the end of the study period, 60% of the subjects from the active study formulation group showed improvement. It was therefore established that phytosterols were responsible for the actions of saw palmetto and are effective 5-α-reductase inhibitors against AGA (Chatterjee and Agrawala, 2003; Prager et al, 2002).

Cho et al (2014) conducted a study to investigate the efficacy of pumpkin seed oil (PSO) on AGA patients. The study was done over 24 weeks on 76 male patients with mild to moderate alopecia. They received 400mg of PSO per day or placebo and results showed a mean hair count increase of 40% in the PSO group as compared to a 10% increase in the placebo group.

Although positive results were reported by Cho et al, the results were only for vertex AGA. Those for frontal AGA were not reported. Furthermore, a study comparing saw palmetto and finasteride in treating frontal AGA reported negative results for saw palmetto (Verma, 2015). This suggests that phytotherapy is a worthwhile treatment for vertex AGA but its effectiveness in treatment of frontal AGA is still to be established.

Also, although β-sitosterol is an effective inhibitor of 5-α-reductase, it has poor absorption through the intestines (Uphadhyay et al, 2012). However, a strong advantage of phytotherapy over conventional medicine is that no obvious side effects have been observed except in individuals with phytosterolemia, an inherited lipid disorder (Ling and Jones, 1995).


  1. Aldini, R., Micucci, M., Cevenini, M., Fato, R., Bergamini, C., Nanni, C., … Budriesi, R. (2014). Antiinflammatory Effect of Phytosterols in Experimental Murine Colitis Model: Prevention, Induction, Remission Study. PLoS ONE, 9(9), e108112.
  2. Othman, R. A. and Moghadasian, M. H. (2011), Beyond cholesterol-lowering effects of plant sterols: clinical and experimental evidence of anti-inflammatory properties. Nutrition Reviews, 69: 371–382. doi:10.1111/j.1753-4887.2011.00399.x
  3. García MD, Sáenz MT, Gómez MA, Fernández MA. Topical anti-inflammatory activity of phytosterols isolated from Eryngium foetidum on chronic and acute inflammation models. Phytother Res. 1999;13:78–80. doi: 10.1002/(SICI)1099-1573(199902)13:1<78::AID-PTR384>3.0.CO;2-F
  4. Rocha, Viviane Z. et al., Effects of phytosterols on markers of inflammation: A systematic review and meta-analysis, Atherosclerosis , Volume 248 , 76 – 83
  5. Liang T, Liao S. Growth suppression of hamster flank organs by topical application of gamma-linolenic and other fatty acid inhibitors of 5alpha-reductase. J Invest Dermatol 1997;109(2):152–7. 21.
  6. Liang T, Liao S. Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids. Biochem J 1992;285(Pt 2):557–62. 22.
  7. Delos S et al. Testosterone metabolism in primary cultures of human prostate epithelial cells and fibroblasts. J Steroid Biochem Mol Biol 1995;55(3–4):375–83.
  8. Cho, Y. H., Lee, S. Y., Jeong, D. W., Choi, E. J., Kim, Y. J., Lee, J. G., … Cha, H. S. (2014). Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial.Evidence-Based Complementary and Alternative Medicine : eCAM, 2014, 549721.
  9.  Prager N. A randomized double-blind placebo controlled trial to determine the effectiveness of botanically derived inhibitors of 5 alpha reductase in the treatment of androgenetic alopecia. J Altern Complent Med. 2002;8:413–52. [PubMed]
  10. Fasculo C. Effectiveness of serenoa repens in androgenetic alopecia. JDDG, 6.2004 (Band 2) 552 abstracts, 4th intercontinental meeting of hair research societies. 2004. Jun 17-19,
    Tosti A. Abstract book, 13th Annual meeting of European Hair research society. Genoa, Italy: 2008. Ketoil® shampoo (ketaconazole 0.5%, serenoa repens, taurine) Vs ketaconazole 1% shampoo (Triatop®) in patients with dandruff and seborrheic dermatitis; pp. 3–5.
  11. Trüeb, R. M. (2009). Oxidative Stress in Ageing of Hair. International Journal of Trichology, 1(1), 6–14.
  12. Lee, B. H., Lee, J. S., & Kim, Y. C. (2016). Hair Growth-Promoting Effects of Lavender Oil in C57BL/6 Mice. Toxicological Research, 32(2), 103–108.
  13. Chatterjee, S. and Agrawala, S.K., Saw Palmetto (Serenoia repens) In Androgenic Alopecia: An Effective Phytotherapy, Natural Product Radiance, 2003 Nov- Dec; 2(6):302-304
  14. Cho, Y.H., Lee, S.Y., Jeong, D.W., Choi, E.J., Kim, Y.J., Lee, J. G., Yi, Y. H. and Cha, H. S., Effect Of Pumpkin Seed Oil On Hair Growth In Men With androgenic Alopecia: A Randomised Double-blind, Place-controlled Trial, Evidence-Based Complementary and Alternative Medicine, 2014 Apr,
  15. Ling, W.H. and Jones, P.J., Dietary Phytosterols: A Review Of Metabolism, Benefits And Side-effects, Life Science, 1995; 57(3):195-206
  16. Prager, N., Bickett, K., French, N. and Marcovici, G., A Randomised, Double-blind, Placebo-controlled Trial To Determine The Effectiveness Of Botanically-derived Inhibitors of 5-α-reductase In The treatment Of androgenic Alopecia, Journal of Alternative medicine, 2002 Apr; 8(2):143-52
  17. Upadhyay, K., Gupta, N.K. and Dixit, V.K., Development And Characterisation Of Phyto-vesicles Of β-sitosterol For The Treatment of Androgenic Alopecia, Archives of Dermatological research, 2 012 sep; 304(7):511-9
  18. Verma, H., Comment On “Effect Of Pumpkin Seed Oil On Hair Growth In Men With Androgenic Alopecia: A Randomised Double-blind, Place-controlled Trial”, Evidence-Based Complementary and Alternative Medicine, 2015 Mar. doi: 10.1155/2015/271474
  19. Woelfle, U. et al, Which Plant For Which Skin Disease? Part 2: Dermatophytes, Chronic Venous Insufficiency, Photoprotection, Actinic Keratosis, Vitiligo, Hair Loss, Journal der Deutscen Dermatologischen Gesellschaft, 2010 Nov (band 8).

Thymosin: Triggering Hair Growth at a Cellular Level

Taylor et al (2000) and Oshima et al (2001) observed that the process of hair growth utilizes many cellular and molecular mechanisms common to angiogenesis and wound healing. While studying the influence of thymosin beta-4 (Tβ4) on wound healing, Philp et al (2004) accidentally found that hair grew more rapidly around the edges of wounds. In due course, they showed that Tβ4 induced rapid hair growth on the dorsal skin of healthy mice (Figure 1). In this study, the increased number of anagen hairs was retained over the entire treatment period but decreased to control levels within 14 days of treatment cessation.

Thymosin for hair growth study results
Figure 1
Source: Philp et al 2004

a) Control vehicle-treated rat skin after 7 days.
b) Control vehicle-treated mouse skin after 28 days.
c) Gross appearance of control vehicle-treated mouse skin after 28 days.
d) Rat skin after 7 days of thymosin β4 treatment.
e) Mouse skin after 28 days of thymosin β4 treatment.
f) Gross appearance of mice after 28 days of thymosin β4treatment.

Similarly, rat whiskers grown in vitro showed rapid growth when treated with Tβ4 (Philp et al, 2007). Upon examination, high levels of Tβ4 expression were observed in the developing hair follicles. Additionally, Tβ4 expression was also found to be high in the developing hair follicles of mice in vitro for 7–10 days (Cha H-J et al, 2010). This confirmed that Tβ4 promotes hair growth.

Meier et al (2012) conducted a study on human hair follicles in organ culture and demonstrated that thymic peptides are produced by the human hair follicle epithelium and function as direct modulators of hair growth. They also suggested that thymic peptides may be therapeutically exploited for stimulating or inhibiting hair growth.

It has long been claimed that Tβ4 stimulates human hair growth (Renner et al., 1986; Sawaya and Shapiro, 2000), but studies showing how it modulates human hair growth are limited. Therefore, although the above studies establish the basis for the further exploration of Tβ4 function and its molecular mechanisms in hair growth, clinical studies need to be performed to assess its possible role in the treatment and prevention of hair loss.


  1. Cha, H-J., Philp. D., Lee, S-H., Moon, H-S, Kleinman, H.K., et al. (2010), Over-Expression Of Thymosin Beta4 Promotes Abnormal Tooth Development And Stimulation Of Hair Growth, The International Journal of Developmental Biology 54: 135–140. doi:10.1387/ijdb.082735hc [PubMed]
  2. Meier. N, Langan, D., Hilbig, H., Bodo, E., Fargo, N.P. et al. (2012), Thymic Peptides Differentially Modulate Human Hair Follicle Growth, Journal of Investigative Dermatology, 2012 Mar;(132):1516 – 19
  3. Oshima, H., Rochat, A., Kedzia, C., Kobayashi, K., and Barrandon, Y. (2001) Morphogenesis And Renewal Of Hair Follicles From Adult Multipotent Stem Cells, Cell 104, 233 – 245
  4. Philp, D., Nguyen, M., Scheremeta, B., St-Surin, S., Villa, A.M., et al. (2004), Thymosin Beta4 Increases Hair Growth By Activation Of Hair Follicle Stem Cells, FASEB J 18: 385–387. [PubMed]
  5. Philp, D., St-Surin, S., Cha, H.J., Moon, H.S., Kleinman, H.K., et al. (2007), Thymosin Beta 4 Induces Hair Growth Via Stem Cell Migration And Differentiation, Ann N Y Acad Sci 1112: 95–103.
  6. Renner. D., Schuster. D., Heim, M.E. (1986), Experiences Using The ‘‘Thymus-Skin’’ Hair Cure For The Prevention Of Alopecia In Cytostatic Treatment, Onkologie 5:285–6
  7. Sawaya, M.E. and Shapiro, J. (2000), Alopecia: Unapproved Treatments Or Indications, Clin Dermatol 18:177–86
  8. Taylor, G., Lehrer, M.S., Jensen, P.J., Sun, T.T. and Lavker, R. M. (2000) Involvement Of Follicular Stem Cells In Forming Not Only The Follicle But Also The Epidermis, Cell 102, 451- 461

Great Experience!

I know a lot about hair loss. I’ve been trying to stop my hair loss for over 10 years with varying degrees of success. I’ve tried just about every treatment you can try. I’ve done LLLT. I used high strength minoxidil for several years. That seemed to really help at first but then like everything else I’ve tried, results diminished pretty quickly.

I used Propecia for a few years. I really thought that would do something, but it didn’t really do much for me.

I’ve also tried a tonne of alternative treatments like supplements, chemicals, etc. Same story. Limited success.

So, onto this method that I stumbled upon roughly a year and a half ago…

I read it and I was impressed. Every instruction is backed up with scientific proof. It’s pretty good.

As far as results go I’ve had better hair regrowth using this method than I’ve had with any other treatments I’ve used. That said, I haven’t seen the kind of hair regrowth some of the other members have seen. I’m a little older than those guys though so I expect it to be a little harder for me.

The guys who put the program together have clearly put a lot of effort into it. It’s not some cheap eBook that just rewrites stuff off the net. It’s serious stuff. I won’t go so far to say this method is genius but it’s not far off.

It’s really not like anything I’ve seen in the forums and I’ve been following the forums for two years. In the back of my mind I didn’t think I’d learn anything new from this. But I was wrong, this really is worth a read.

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More people should know about this stuff

My experience of Advanced Hair Research was very pleasant. At first something went wrong with my order confirmation email (I didn’t receive it). But Chris emailed me within a few hours of making my order to tell me my Paypal email address was not working and my order confirmation email had bounced back, so he sent me a very nice email introducing me to the method personally!

I was in a fairly desperate situation with my hair. It was getting thinner and thinner every day and making me feel like an old man. I didn’t know whether there was something wrong with me, like if I had a medical condition I didn’t know about or something.

So I bought the Advanced Hair Research method with the hope that it would help fix whatever was wrong with me. My brothers are both older than me and they are not losing their hair particularly.

I was quite shocked at how sophisticated this method is. It’s really something. I think this is exactly what I needed. I was in a really bad state before I started the method. I looked unhealthy, I didn’t sleep particularly well and I felt stressed a lot.

Basically my hormones were out of balance. Too much of the wrong hormones (stress hormones and androgen hormones) and not enough of the good hormones that make you feel good, focused and energetic. This is exactly what I needed to get my hormonal balance and my mind back to healthy.

I had to post this review because this method really has changed my life. Not just a little bit but a lot. Not only is my hair now growing back but I also feel right. Before I always felt somehow wrong. Like I was slightly ill or tired or anxious. Now I feel amazing every day. I have amazing energy. I feel good in the morning. I feel positive. And I think these things are really important. If you fix the underlying problems in your body things like hair loss and skin problems heal themselves. That’s what seems to have happened to me.

When I get time I’ll post my before and after pictures to

It’s been an experience that I’m glad I went through. I’ve found out more about myself. I found out I can be anything I want to be if I have the confidence and I don’t let things get me down. You have to be positive, sleep well and feel healthy if you want to be healthy. I think hair loss is a symptom of bad health. And I’m glad my hair loss has completely stopped and that my hair is growing back but I’m even more glad that I’ve fixed my unbalanced body and I can live the way I know I was supposed to live.

I want to say thanks Chris. It really means a lot to me what you’ve done. More people should know about this stuff. I had no idea. I feel very lucky that I found your website.

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Taurine for Hair Growth — the Most Effective Amino Acid for Fighting Hair Loss?

Taurine supplement

Taurine, also known as 2- aminoethanesulfonic acid, is an organic compound that can be found in animal tissue and has a vital function in both animals and humans.

Its primary biological roles in humans are:

  • to conjugate bile acids;
  • osmoregulation;
  • antioxidation; and
  • modulation of calcium signalling

Taurine has been proved beneficial for regulating blood pressure and vasoactivity

Taurine is found in the brain, heart and blood cells called platelets and it’s considered a conditional amino acid which means that it is produced by the body. (Schuller-Levis and Park, 2003)

Taurine Benefits

There is clear research showing that taurine supplementation has benefits in various medical fields.

Taurine has been proven beneficial for:

  • regulating blood pressure and vasoactivity;
  • it’s neuroprotective role (Frye et al., 2013);
  • Beneficial effects on high blood pressure ( El Idrissi et al.2013)
  • Beneficial effects on high cholesterol (Wójcik et al., 2009, 2012),
  • improving seizures and autism (Ghanizadeh, 2013), and
  • improving mental performance (Seidl, 2000)

Other studies show that there are increased health benefits when it comes to congestive heart failure and taurine supplements may improve or even treat this condition or other heart related conditions. It’s important to state that taurine could also serve as a great preventative and adjuvant in treatments for people predisposed to any of the conditions above. (Xu et al., 2008)

How is Taurine linked to Hair Regrowth?

The observations concluded that taurine protects the hair follicle from the effects of (TGF)-β1 as well as promoting hair survival

There are several studies showing the benefits of taurine on hair growth and overall health, as well as its connection with the hair’s natural growing cycle.

One study in 2013 (Kim et al.) describes alopecia as a modern malady that is aggravated by stress due to the changing socio-economic conditions we are living.

Researchers studied the effects of taurine against alopecia that has been caused by various chemical stress agents. There was a positive response when taurine was added and it allowed better stress recovery. The study concludes that there is strong evidence showing how taurine can help with alopecia, especially when used with other treatments that reduce hair loss.

Another study conducted in 2008 (Collin et al.) analyses taurine in relation to (TGF)-β — a protein that may cause hair loss. Taurine is involved in many physiological functions among which the immunomodulatory and antifibrotic functions. The researchers used taurine on in-vitro hair follicles. The observations concluded that taurine protects the hair follicle from the effects of (TGF)-β1 as well as promoting hair survival.

besides being an important element in brain and retinal development, taurine has a great anti-inflammatory and antioxidant effect

The (TGF)-β1 is a protein that performs various functions such as cell growth, cell proliferation, cell differentiation, etc.; it also plays an important role in the fibrosis of hair follicle and its growth.

There is further research that shows how (TGF)-β1 is linked to androgenetic alopecia as an important factor in hair growth. This particular study concludes that (TGF)-β1 derived from DPCs mediates hair growth suppression in AGA. (Kim et al.,2013)

Taurine as an anti-inflammatory

Taurine’s anti-inflammatory effect might also help reduce inflammation, thus helping those with scarring alopecia as well as micro inflammation that is due to external factors. In fact it’s thought that inflammation plays a major role in male pattern hair loss, caused by DHT.

A study in 2013 (Kim et al.) concluded that besides being an important element in brain and retinal development, taurine has a great anti-inflammatory and antioxidant effect. The study also shows that taurine inhibits the pro inflammatory mediators resulting from TLR9 activation. This may help researchers find treatment and even a cure for conditions like alopecia areata, psoriasis, vitiligo or other autoimmune conditions.

Hibino & Nishiyama argue that hair loss can be easily prevented by understanding how DHT stimulates synthesis of (TGF)-β1 in derma papilla cells. (TGF)-β1 also suppresses the proliferation of epithelial cells and stimulates synthesis of some caspases. Ultimately, epithelial cells are eliminated through apoptotic cell death. The study concludes that (TGF)-β1 antagonists help by preventing morphological changes as well as promoting the elongation of hair follicles. (Hibino & Nishiyama, 2004)

There is significant evidence showing how taurine is linked to (TGF)-β1 and can be used in treatment of hair loss. One study on taurine deficiency further supports the link between taurine and (TGF)-β1 (Hagiwara et al., 2014) while another study shows that taurine inhibits the expression of procollagen type I and type III in lung fibrosis, once again linking taurine to (TGF)-β1. (Gurujeyalakshmi, Hollinger & Giri, 1998)

Another study on taurine supplementation in the treatment of women with hair fragility shows the potential benefits of a systematic taurine supplementation; the study was conducted on 20 women with ages between 20 to 68 years who had fine hair and decreased hair thickness and shows that daily oral intake of taurine 150mg, Catechin 75mg and Zinc 15mg is beneficial to hair health. 11/12 women showed increased hair diameter from 0,040 to 0,045 μm while 6 other women showed an increase from 0,040 to 0,043 μm. (Tosti et al., 2007)

Natural Taurine Sources

Considering how many benefits taurine has to humans, it’s only logical to look into ways to supplement our taurine intake every day. Fortunately, besides oral supplements, there is a plethora of options for those who simply want to increase their taurine intake naturally.

A paper in 2009 (Oktawia et al.) reviewed taurine content of various foods and the most rich in taurine are:

  • beef
  • chicken
  • turkey
  • veal
  • pork loin
  • lamb
  • ham.

Seafood is also extremely rich in taurine with clams, octopus, scallop, squid and white fish being the most taurine rich foods. Taurine cannot be found in plants except sea algae so vegetarians and vegans should consider monitoring their taurine levels and take supplements if needed.

Energy drinks contain a very high amount of taurine (between 1000mg to 3000mg) as well as high caffeine content. However, it’s unknown whether the high caffeine content may have detrimental effects on health.

Numerous studies indicate that taurine has tremendous benefits for our overall health. While some of the studies have led to revolutionary treatments in certain areas such as proposing it as adjuvant treatment for cardiovascular disease, a specific treatment model for hair loss that incorporates taurine hasn’t been furthered yet. Although there isn’t sufficient data showing that taurine by itself cannot cure hair loss, it is an essential discovery that may pave the path for further hair loss treatments.


  1. Georgia B. Schuller-Levis, Eunkyue Park, Taurine: new implications for an old amino acid, FEMS Microbiology Letters Sep 2003, 226 (2) 195-202; DOI: 10.1016/S0378-1097(03)00611-6 Link:
  2. Frye, R. E., Rossignol, D., Casanova, M. F., Brown, G. L., Martin, V., Edelson, S., … Adams, J. B. (2013). A Review of Traditional and Novel Treatments for Seizures in Autism Spectrum Disorder: Findings from a Systematic Review and Expert Panel. Frontiers in Public Health, 1, 31.
  3. Abdeslem El Idrissi , Evelyn Okeke, Xin Yan, Francoise Sidime, Lorenz S. Neuwirth, Taurine Regulation of Blood Pressure and Vasoactivity, Volume 775 of the series Advances in Experimental Medicine and Biology pp 407-425, 10 January 2013 Link:
  4. Wójcik, O. P., Koenig, K. L., Zeleniuch-Jacquotte, A., Costa, M., & Chen, Y. (2010). The potential protective effects of taurine on coronary heart disease. Atherosclerosis, 208(1), 19.
  5. Wójcik, O. P., Koenig, K. L., Zeleniuch-Jacquotte, A., Pearte, C., Costa, M., & Chen, Y. (2013). Serum taurine and risk of coronary heart disease: a prospective, nested case-control study. European Journal of Nutrition, 52(1), 169–178.
  6. Ghanizadeh, A. (2013). Increased Glutamate and Homocysteine and Decreased Glutamine Levels in Autism: A Review and Strategies for Future Studies of Amino Acids in Autism. Disease Markers, 35(5), 281–286.
  7. R. Seidl, A. Peyrl, R. Nicham, E. Hauser, Taurine and caffeine-containing drink stimulates cognitive performance and well-being, Amino Acids 19(3-4):635-42 · February 2000 Link:
  8. Xu, Y.-J., Arneja, A. S., Tappia, P. S., & Dhalla, N. S. (2008). The potential health benefits of taurine in cardiovascular disease. Experimental & Clinical Cardiology, 13(2), 57–65.Link:
  9. Hyemin Kim, Hyunsook Chang, Dong-Hee Lee, Simulative Evaluation of Taurine Against Alopecia Caused by Stress in Caenorhabditis elegans, 2013, Volume 776 of the series Advances in Experimental Medicine and Biology pp 267-276, Link:
  10. Collin, C., Gautier, B., Gaillard, O., Hallegot, P., Chabane, S., Bastien, P., Peyron, M., Bouleau, M., Thibaut, S., Pruche, F., Duranton, A. and Bernard, B. A. (2006), Protective effects of taurine on human hair follicle grown in vitro. International Journal of Cosmetic Science, 28: 289–298. doi: 10.1111/j.1467-2494.2006.00334.x Link:
  11. Kim BS, Spinner DS, Kascsak RJ, Park SY, Cho IS, Schuller-Levis G, Park E., Inflammatory mediators are inhibited by a taurine metabolite in CpG oligodeoxynucleotide and IFN-r activated macrophage cell line. J Drugs Dermatol. 2013 May;12(5):551-7. Link:
  12. Hibino, Toshihiko et al.,Role of TGF-β2 in the human hair cycle, Journal of Dermatological Science , Volume 35 , Issue 1 , 9 – 18, Link:
  13. Hagiwara, A., Ishizaki, S., Takehana, K., Fujitani, S., Sonaka, I., Satsu, H., & Shimizu, M. (2014). Branched-chain amino acids inhibit the TGF-beta-induced down-regulation of taurine biosynthetic enzyme cysteine dioxygenase in HepG2 cells. Amino Acids, 46(5), 1275–1283.
  14. G. Gurujeyalakshmi, M. A. Hollinger, and S. N. Giri “Regulation of Transforming Growth Factor- β1 mRNA Expression by Taurine and Niacin in the Bleomycin Hamster Model of Lung Fibrosis”,American Journal of Respiratory Cell and Molecular Biology, Vol. 18, No. 3 (1998), pp. 334-342.doi: 10.1165/ajrcmb.18.3.2867 Link:
  15. Tosti, Antonella; Vincenzi, Colombina; Starace, Michela; Pazzaglia, Massimiliano; Department of Dermatology University of Bologna, Bologna, Italy Oral Supplementation With Taurine in the Treatment of Women With Hair Fragility Link:

New version is much better

I bought the old version of Chrises method years back but didn’t really get much hair regrowth from that. It slowed down my hair loss but that’s about it.

I saw a review here last year and it was for a new version of the method that sounded a lot better. So I asked Chris for the new version.

This new version has made a big difference for me. I am finally regrowing my hair! Believe me when I say this is miraculous after everything I’ve been through! I feel like I have tried every hair loss treatment known to man and nothing has worked. Finally I’m regrowing my hair. You guys are the best! Thank you so much guys . And thank you for the free updates!!! This is really amazing.

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New Hair Loss Treatments: The Latest, Most Advanced Treatments available in 2016/2017

The most popular hair loss treatments of today are rarely 100% successful and often come with side effects.

People are fed up with the ineffectiveness of popular treatments and some are taking their own initiative by using unapproved medication to treat their hair loss.

Fortunately, the early adopters’ interest in curing hair loss is paying off in some areas and the future looks bright — even for those with complete baldness — thanks to new discoveries and treatments that are currently being researched.

The following are 5 of the most promising discoveries in hair loss treatment that will be available in the near future and might completely change the way we approach hair loss.

JAK Inhibitors Treatment

The trials have shown that mice receiving Ruxolitinib and Tofacitinib regrew new hair within ten days

New research has shown that Janus-kinase inhibitors, also known as “JAK inhibitors”, could be the answer we’ve been looking for in the treatment of alopecia areata. The effects of JAK inhibitors on hair regrowth was accidentally discovered during a study of Tofacitinib as a treatment for psoriasis.

by applying JAK inhibitors topically we are able to control the hair growth mechanism and help the hair follicle revert to the anagen phase

One patient who was treated hadn’t had any hair growth in 7 years. However, at the end of his trial, his hair had regrown.

The latest study from Columbia University confirms that JAK inhibitors such as Ruxolitinib and Tofacitinib may have a positive effect on hair growth.

The study was based on JAK enzymes’ involvement in the hair growth cycle: in alopecia areata, the baldness is caused by the hair follicles getting stuck in the telogen phase due to an auto immune response. This auto immune disease can be caused by stress or a sudden shock and this disrupts the normal hair growth cycle. JAK treatments target the enzymes inside the hair follicles to go beyond the telogen phase and resume their normal growth cycle.

Tofacitinib JAK inhibitor for hair loss

The trials have shown that mice receiving Ruxolitinib and Tofacitinib regrew new hair within ten days from administration. The findings suggest that by applying JAK inhibitors topically we are able to control the hair growth mechanism and help the hair follicle revert to the anagen phase.

Furthermore, the treatment regulates the activation of key hair follicle populations as well as improving the inductivity of cultured human dermal papilla cells. There are also at least two additional clinical trials that are trying to show the effects of Tofacitinib as a treatment for severe hair loss such as Alopecia Totalis and Alopecia Universalis as well as teams trying to concentrate on male and female pattern baldness.

Stem Cell Based Treatment for Baldness

Researchers from the University of Pennsylvania and the New Jersey Institute of Technology have developed a new way to generate a significant amount of hair follicle generating stem cells from adult cells.

The technique converts adult cells from humans into epithelial stem cells. Pluripotent stem cells were converted into epithelial stem cells that are found in hair follicles. The conversion usually lasts 18 days and about 25% of the pluripotent stem cells are successfully converted into epithelial stem cells.

Researchers were surprised to see the regenerating effects of the cells when they were mixed with follicular inductive dermal cells and then grafted on the skin of mice. The cells produced hair follicles but they may have other dermatological applications.

This treatment is still being researched. In order to achieve a more complete picture of success there is a need to recreate the dermal papillae cells — adults who lose their epithelial cells also lose the dermal papillae cells, which brings us to our next revolutionary new hair loss treatment.

Shiseido and Replicel Treatment

The cells are then replicated into millions of other cells and added to the scalp

Shiseido has promised to come up with another commercial treatment for baldness in 2018 by pairing up with Replicel Life Sciences. The company is known for developing a revolutionary hair loss treatment known as RCH-01.

Replicel has created a method for converting mature cells into pluripotent stem cells that will be later converted into derma papilla cells. The treatment created by Shiseido and Replicel starts by extracting hairs from the scalp at the root level in order to isolate a specific cell population from a person’s healthy hair growing scalp areas. The cells are then replicated into millions of other cells and added to the scalp by injecting them into the areas where hair doesn’t grow.

Although this treatment will probably not be suitable for home-use, it has been speculated that it might become a standard procedure in hair loss treatment centres.

Foreign Donor Hair Cloning

The hair follicles are taken from a person with a healthy scalp, multiplied in the lab and then re-implanted into the recipient scalp

The researchers at Bernstein Medical Center for Hair Restoration are currently working on a new hair loss treatment that seeks to transplant hair follicles from one donor individual to another recipient individual.

Research suggests that dermal sheath cells can be isolated from one person and then injected to the scalp of another person in order to produce the formation of new hair. The treatment is extremely promising for Androgenic Alopecia and involves moving hair follicles from one person, perhaps even of another gender, to another person’s scalp and it is suggested it may work for people who have been completely bald for years.

The hair follicles are taken from a person with a healthy scalp, multiplied in the lab and then re-implanted into the recipient scalp: these hair follicles can be multiplied in unlimited amounts.

The hair follicles cells will eventually grow new and healthy and permanent hairs. This not only means that the patient will have a healthy hair but also that they will be completely cured of hair loss.

One of the major problems with this treatment is finding an environment that would allow the cells to grow in a state that is differentiated as to not become fibroblasts again.

Histogen Treatment For Hair Loss

it was shown that 84.6% of the patients receiving the substance had a significant increase of hair count after 12 weeks

Histogen is one of the new substances being researched for the treatment of hair loss. Known as the Hair Stimulating Complex (HSC), the substance is produced by growing neonatal cells under hypoxia + suspension, thus making them multipotent. The proteins involved in HSC , such as Follistatin, VEGF and KGF are known to signal stem cells in the body to start hair formation and stimulate hair follicles.

The product is already in clinical trials and will probably be commercially available in the near future. In the HSC pilot trial it was shown that 84.6% of the patients receiving the substance had a significant increase of hair count after 12 weeks. Another clinical trial showed that the total hair count was 45.5% more than the results seen in the pilot. After one year, the hair growth parameters in the patients that underwent the treatment were above the baseline. Another important aspect is that other trials showed the product works just as well for women as it does for men. Even more, the product shows no toxicity or abnormalities in clinical trial follow-ups with minimal adverse effects.


  1. JAK trials

    Alopecia Treatment Update on JAK Inhibitors Ruxolitinib and Tofacitinib

  2. Stem Cell Research
  4. Replicel

    Shiseido Partners With RepliCel to Launch Hair Loss ‘Cure’ in 2018

  5. Hair Cloning
  6. Histogen treatment

Strong Evidence Backs-up Soy Isoflavones for Hair Loss

Soy Isoflavones

Soybean, also known as Glycine max is a versatile legume native to East Asia that has been linked to reversing or even preventing hair loss. The high content of isoflavones, as well as iron, calcium and vitamins helps with hair loss by reducing DHT while increasing the Insulin-like growth factor-I (IGF-I), collagen and small blood vessel circulation.

The key is in the isoflavones

Soybeans contain isoflavones, which are similar to the female hormone called estrogen and they can act as partial or total antagonists to endogenous estrogens, phytoestrogens and xenoestrogens. They are also considered antioxidants and inhibitors of proteases, tyrosine kinases and angiogenesis.

Besides their antagonist effect, they can also alter steroid metabolism by inhibiting hydroxysteroid dehydrogenase, steroid alpha-reductase and aromatase. (Barrett, 2006)

New research shows that adding soy in your diet will improve the look of your skin and hair but also benefit those who are experiencing hair loss. A paper on the nutrition of postmenopausal women with hair loss problems suggests soy to be not only an isoflavone source but also as a rich iron source, since hair loss is sometimes associated with a deficit of iron. (Goluch-Koniuszy 2016). The study suggests that a mix of proteins, panthotenic acid, iron, calcium and isoflavones, all found in soy and soy products, allow the prevention of hair loss, while keeping hair fibres strong, thick and maintaining natural hair colour and also delaying hair graying for longer periods of time.

Isoflavones as a DHT blocker

The group that consumed high isoflavone soy protein isolate showed a significant decrease in DHT levels

DHT is known to influence the hair growth cycle: the follicles shrink and they no longer produce hair, the hair begins to fall out as the hair follicle cycle survival is shorter, and in the end, hair will stop being produced and microscopic scarring will result from this process. Current treatment for hair loss includes DHT blockers or vasodilators, but they can come with a huge list of side effects and not all people with hair loss can follow the treatment. There are also alternate solutions, from herbal medicine to topical solutions, but even then, the treatment is not 100% safe and successful for everybody. (Barrett, 2006)

A study in 2005 (Dillingham et al.) showed inverse association between soy and prostate cancer with some serious implications for hair loss as well. 35 men consumed milk protein isolate, low isoflavone soy protein isolate and high isoflavone soy protein isolate for 57 days. The group that consumed high isoflavone soy protein isolate showed a significant decrease in DHT levels. This means that there is a link between DHT production and dietary supplementation of isoflavone and that regardless of isoflavone content in soy protein, it always reduces DHT levels with only minor effects on other hormones.

Isoflavones as an IGF-1 and hair growth stimulator

There is some evidence that soy proteins may play a role in hair growth – a study on mice (Zhao et al., 2011) showed that dietary isoflavone increases insulin-like growth factor-I production and promotes hair growth. The study lasted 3 weeks in which isoflavone was administered to mice; it significantly increased the immunohistochemical expression of IGF-I in hair follicle derma papilla cells. Hair regrowth, hair pigmentation and enhancements in the hair follicle morphogenesis were also observed suggesting that isoflavone supplementation might promote hair growth.

Evidence suggests a combination of isoflavones and capsaicin produce best hair growth results

Organic cayenne pepper

Another study (Naoaki, 2007) showed that the administration of capsaicin and isoflavones promotes hair growth both in mice and humans with hair loss. The volunteers with hair loss who followed a capsaicin and isoflavones diet showed significant hair growth after 5 months of administration due to an increase of IGF-I production in the hair follicles. Isoflavone from soy and soy products achieves this by increasing production of calcitonin gene-related peptide (CGRP), which increases production of Insulin-like growth factor-I (IGF-I), thus, promoting hair growth.

Isoflavones may also be a powerful anti aging tool

The increase in blood vessels led to better circulation of the scalp which helps with hair regrowth

It seems that isoflavones also help with various health issues related to skin and hair. A study on 30 postmenopausal women showed significant health benefits when isoflavones were supplemented by 100mg/day. The results showed that isoflavone treatment increased the epidermis thickness by 9.46% in 23 out of the 30 women who participated in the study; the collagen amount in the skin as well as the number of elastic fibres increased. Furthermore, the number of dermal blood vessels was increased significantly, which does suggest that isoflavons have a beneficial effect to the skin and the blood vessels. (Accorsi-Neto et al., 2009)

The increase in blood vessels led to better circulation of the scalp which helps with hair regrowth while the increase in the collagen amount gives hair better flexibility and strength, preventing, dry, brittle damaged hair.
A research paper on the lifestyle and environmental factors that contribute to hair loss, showed that patients from Taiwan who had less soy in their diet were more at risk of develop hair loss. The study investigated the blood and urine heavy metals concentrations, environmental factors, dietary intakes, work hours, sleep patterns, genotypes of certain susceptibility genes and personal behaviour of men aged 35 to 75 years of age. (Lai et al., 2013) The research suggested that isoflavones from soy and soy products prevented hair loss by modulating estrogen dependent mechanisms and reducing inflammatory activity.

Adding more soy in your diet doesn’t just improve your health and prevent certain cancers but it may also help with hair loss. Tofu, soy milk or texturized soy are easy to add to your diet, either as adjuvants to your hair loss treatment or to see whether they can help you stop hair falling and maintain your existing hair by blocking DHT. Although there isn’t any treatment pattern that may include soy or any big trial study that uses soy as a treatment, soy is a natural and safe ingredient that promises to change the way we see hair loss treatments and the fact that we can approach them from a nutritional level.

References and further reading

  1. Barrett, J. R. (2006). The Science of Soy: What Do We Really Know?Environmental Health Perspectives, 114(6), A352–A358. S
  2. Harada, Naoaki et al. Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia Growth Hormone & IGF Research , Volume 17 , Issue 5 , 408 – 415
  3. Zhao, Juan et al. Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice Journal of Nutritional Biochemistry , Volume 22 , Issue 3 , 227 – 233
  5. Dillingham BL, McVeigh BL, Lampe JW, Duncan AM Soy protein isolates of varying isoflavone content exert minor effects on serum reproductive hormones in healthy young men, J Nutr. 2005 Mar ; 135(3): 584-91
  6. Accorsi-Neto A, Haidar M, Simões R, Simões M, Soares-Jr J, Baracat E. Effects of isoflavones on the skin of postmenopausal women: a pilot study. Clinics. 2009;64(6):505-10.
  7. Lai, C.-H., Chu, N.-F., Chang, C.-W., Wang, S.-L., Yang, H.-C., Chu, C.-M., … Liou, S.-H. (2013). Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities. PLoS ONE, 8(12), e79789.
  8. Jin-Rong Zhou, Lunyin Yu, Ying Zhong and George L. Blackburn Soy Phytochemicals and Tea Bioactive Components Synergistically Inhibit Androgen-Sensitive Human Prostate Tumors in MiceJ. Nutr. 2003 133: 2 516-521
  9. Goluch-Koniuszy, Z. S. (2016). Nutrition of women with hair loss problem during the period of menopause. Przegla̜d Menopauzalny = Menopause Review,15(1), 56–61.

Lysine for hair loss: how this amino acid makes hair grow

Lysine or L-Lysine is an essential amino-acid.

A lysine deficiency is linked to a multitude of health problems; from anemia to hair loss.

One of the main arguments that Lysine is a suitable treatment for hair loss is due to its restorative properties on the hair follicle. Research shows that people with insufficient lysine in their diet might be at risk of hair breakage, reduced hair growth and, ultimately, hair loss.

Blocking 5-alpha Reductase

fewer cases of male pattern baldness in Asians might be due to their diet being rich in L-Lysine

It seems that Lysine is associated with blocking the enzyme 5-alpha reductase — an enzyme which converts testosterone to DHT, which causes male-patterned baldness. Lysine also helps strengthen hair cells due to its role in the absorption of calcium, which has an essential role in creating collagen for hair, skin, or nails.

Rushton et al. (2002) reports that a major cause of hair loss before the age of 50 in women is related to nutrition, which may cause baldness in 30% of women. This is mostly due to the lack of iron combined with low levels of L-lysine and correcting these imbalances may stop excessive hair loss and even regrow hair that has been lost.

One of the studies that spiked interest in using Lysine for hair loss was when researchers (Anwar et al. 1997) observed that male pattern baldness was less common in Asians than Americans. They analysed the standard diets of American men and compared it with the standard diet of Asian men and concluded that the fewer cases of male pattern baldness in Asians might be due to their diet being rich in L-Lysine, which affected 5-alpha-reductase.

Reducing Cortisol (Stress Hormone) Levels

Another way Lysine may be connected with hair loss is by reducing cortisol levels. (Smriga et al.,2007) Many of the people experiencing hair loss, might not be genetically predisposed to it because one of the main causes of hair loss is experiencing stress and anxiety. People who deal with stress badly may have low levels of Lysine and high levels of cortisol, both of which may accelerate hair loss.

A study on males from Japan showed that people can decrease their stress and anxiety by taking L-lysine and L-arginine orally. The supplementation worked by decreasing the levels of salivary cortisol and chromogranin.

People who are experiencing hormonal hair loss have high levels of cortisol. Due to the fact that Lysine appears to lower cortisol there seems to be another link between Lysine levels in the human body and hair loss.

A Clear Link Between Lysine and Hair Growth

Studies on animals showed that lysine may be the key to better hair. Wool follicles and fibres of pre-ruminant lambs that were fed a diet containing little lysine experienced abnormalities such as: incomplete keratinisation, distortion of fibres and partial degradation in the distal parts of the follicles. When the animals were returned on a diet rich in lysine, their hair structure improved rapidly, but abnormalities were still observed in older fibres. (Chapman et al., 1983)

Strong Indications Lysine Prevents Female Hair Loss

subjects receiving treatment experienced a 31% reduction in the amount of hair shed

One of the most important studies on the effects of lysine on hair loss was a double blind and placebo controlled study on 12 women suffering from chronic telogen effluvium. 7 of the women participating in the study received 72 mg of iron and 1.5 g of L-lysine daily for a 6 months treatment while 5 of the women received placebo.

The results showed that the women receiving a treatment of iron and L-lysine had their serum ferritin concentration increased. Also, subjects receiving treatment experienced a 31% reduction in the amount of hair shed compared with a 9% increase in the placebo group (Kantor et al., 2003).

Lysine Lengthens the Hair Growth Stage

Rushton et al. studied 22 women who were given a treatment of 72 mg of iron and 1.5 grams of L-lysine. The women were followed for 6 months and the study showed that the telogen phase of their hair significantly decreased from 19.5% to 11.3%. The telogen phase of the hair is when the hair stops growing, rests and then falls. This phase is significantly longer in people who are experiencing hair loss. The authors concluded that L-lysine and iron supplements seem to correct alopecia that is caused by iron and lysine, especially in the case of women who suddenly suffer from hair loss, and this is sometimes due to a nutrient deficiency caused by hormonal change.

Lysine for Male Pattern Baldness

There were statistically significant differences between the groups receiving treatment and the placebo group

In a study showing the efficacy of a Complex of 5-Aminolevulinic Acid and Glycyl-Histidyl-Lysine Peptide on male pattern hair loss was conducted on 45 patients. The first group was treated with ALAVAX 100mg, the substance mentioned earlier, the second group was treated with ALAVAX 50mg while the third group received a placebo. The treatment lasted for 6 months and the patients were evaluated with the following results: hair count was 52.6 (p<0.05) in group A, 71.5 (p<0.05) in group B, and 9.6 in group C. There were statistically significant differences between the groups receiving treatment and the placebo group. The authors believe that the results are due to the tripeptidecopper complex glycyl-L-histidyl-L-lysine-Cu2+, which can activate wound healing processes and has anti-inflammatory actions. Together with the 5-aminolevulinic acid (5-ALA) it may be available as treatment for patients with male pattern baldness under the name of ALAVAX. (Lee et al., 2016)

Topical Lysine

Crescina hair loss treatment

A new topical treatment for androgenetic alopecia was studied in 2013 (Buonocore et al.). The drug is called Crescina and contains a mix of different substances known to prevent hair loss and promote hair growth. Crescina contains cysteine, lysine, a glycoprotein, hydrolysed rice protein, and corosolic acid.

there was a statistically significant increment of the mean anagen rate

The study was performed on male volunteers suffering from alopecia on a Hamilton-Norwood scale of 2 to 4. The participants were divided into a placebo group and a trial group and had to follow a procedure for 4 months: topically apply one vial of product on a clean and dry scalp and concentrate on areas where the thinning was more pronounced. This treatment was to be applied for 5 consecutive days with 2 days break in between the applications for 4 months.

After 4 months the groups were evaluated and there was a statistically significant increment of the mean anagen rate in the group receiving treatment. It was observed in 95.7% at 2 months and in 100% of the subjects at 4 months. In the placebo group the anagen rate was seen in 56.5% at 2 months and 69.6% at 4 months.

Another benefit of the topical treatment was seen in the pull test where hair resistance to traction in the group receiving treatment was 89.5% at 2 months and 100% at 4 months while the placebo group only had 56.6% at 2 months and 78.9% at 4 months improvement of hair resistance to traction.

The authors concluded that Crescina works for promoting hair growth and inhibiting hair loss. The active ingredients in the treatment may be significantly useful in the treatment of hair loss.

The researchers based their ingredients on their effects as follows: the hydrolysed rice protein and corosolic acid were used in the treatment for stem cell and dermal papilla stem cell proliferation while ingredients such as lysine, cysteine and glycoprotein were used for keratinisation, thus, increasing the strength of hair to mechanical and internal damage.

It’s great news that researchers are also studying the nutritional aspects of hair loss and lysine may be the starting point of a whole new approach to alopecia treatment. Although there are studies linking lysine to hair growth, it needs more clinical trials to see how the amino acid can be made more effective.

References and further reading

  1. Rushton, D. H. (2002), Nutritional factors and hair loss. Clinical and Experimental Dermatology, 27: 396–404. doi:10.1046/j.1365-2230.2002.01076.x
  2. Anwar R, Gilbey S, New J, et. al. Male pseudohemaphroiditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2). Mol Pathol 1997:50:51–52.
  3. Chapman, R.E., Colebrook, W.F. and Black, J.L. (1983) ‘Influence of dietary lysine content on wool follicle function in pre-ruminant lambs’, The Journal of Agricultural Science, 101(1), pp. 139–145. doi: 10.1017/S0021859600036467.
  4. Smriga M, Ando T, Akutsu M, Furukawa Y, Miwa K, Morinaga Y.
    Biomed Res. 2007 Apr;28(2):85-90. Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans. Institute of Life Sciences, Ajimoto Co. Inc, 1-1 Suzuki-cho, 210-8681 Kawasaki-ku, Kawasaki-shi, Japan.
  5. Kantor, J., Kessler, L.J., Brooks, D.G., and Cotsarelis, G. Decreased serum ferritin is associated with alopecia in women. J Invest Dermatol. 2003; 121: 985–988
  6. Rushton, D. H., Norris, M. J., Dover, R. and Busuttil, N. (2002), Causes of hair loss and the developments in hair rejuvenation. International Journal of Cosmetic Science, 24: 17–23. doi:10.1046/j.0412-5463.2001.00110.x
  7. Lee WJ, Sim HB, Jang YH, Lee SJ, Kim DW, Yim SH.   Efficacy of a Complex of 5-Aminolevulinic Acid and Glycyl-Histidyl-Lysine Peptide on Hair Growth.   Ann Dermatol. 2016 Aug;28(4):438-443.
  8. Buonocore, D., Nobile, V., Michelotti, A. et al. Clinical Efficacy of a Cosmetic Treatment by Crescina® Human Follicle Stem Cell on Healthy Males with Androgenetic Alopecia Dermatol Ther (Heidelb) (2013) 3: 53. doi:10.1007/s13555-013-0021-2

Topical Saw Palmetto for Hair Loss: Read This Before Trying

Topical saw palmetto hair loss treatment

Saw Palmetto is one of the most popular natural treatments for hair loss and with just a quick search online you can see thousands of articles about it. But does it really work? Is there any science backing up the cult following surrounding this plant?

Saw Palmetto (serenoa repens) is actually a palm tree in the Arecaceae family and also comes with the name sabal or palmera de Florida. Studies have shown that saw palmetto has similar properties to finasteride, a drug used for enlarged prostate and more an dmore, for hair loss.

Several promising looking topical hair loss treatments containing powerful natural DHT blockers have been introduced to the market in recent years. Here are a few good examples:

  • Topical saw palmetto hair loss treatment
  • Hoffman Topical Saw Palmetto Serum

Saw Palmetto vs Finasteride

the saw palmetto group experienced a distinct increase in hair growth

A study showed that men receiving saw palmetto had moderate response to the treatment versus men receiving finasteride. Even though the finasteride effect was higher, the study concluded that the saw palmetto induced suppression was statistically significant. (Marks et al.,2001)

Another study (Rossi et al., 2012) was conducted to determine how effective saw palmetto was for hair loss prevention and compared its effects with finasteride. The researchers used 100 male patients that were diagnosed with mild to moderate androgenetic alopecia. The patients were split into two groups, one received saw palmetto(320 mg) and the other received finasteride (1mg).

The researchers concluded that the saw palmetto group experienced a distinct increase in hair growth. When compared with the finasteride group, those treated with saw palmetto didn’t have spectacular results. Another difference between the two was the fact that finasteride acted both in the front area and the vertex while saw palmetto acted mostly in the vertex.

Although both studies show that finasteride is superior when it comes to treating hair loss, the fact that saw palmetto’s results are comparable with the drug is noteworthy. The mechanism behind saw palmetto’s effects on the scalp was not conclusive and further study was required to see exactly how saw palmetto works.

How does saw palmetto reduce hair loss?

The extract that is often used as a hair loss treatment is produced from the fruits of the plant which contain a wide array of beneficial elements: flavonoids, fatty acids, plant sterols, etc., which may account for the effects saw palmetto has on the scalp. Studies show that these compounds have anti-inflammatory effects, antioxidant effects, improve blood circulation and some have been researched as successful DHT blockers.

Flavonoids in Saw Palmetto

Saw palmetto contains various flavonoids such as: rutin, isoquercitrin, kaempferol 3-O-glucoside, apigenin 7-O-rhamnoglucoside and anthranilic acid. Some of these flavonoids can have significant benefits for hair and skin. For example, rutin is used as an anti-inflammatory drug in patients with osteoarthritis and it has been shown to improve blood circulation and can be used as an anti-thrombotic and anticoagulant;(Choi et al.,2015) this may help improve circulation in the scalp and nourish the hair follicle.

There’s even a direct link between rutin and hair follicle health. A study (Carelli et al., 2012) on the hair follicle regression focused on the activation of apoptosis (cell death) in the hair follicle cells. The researchers used a combination of rutin, spermidine and zeaxanthin on hair cells and noticed that the cells treated with this combination preserved their anti-apoptotic molecules, concluding that these agents might be an effective treatment for hair bulb regression.

Another flavonoid contained by saw palmetto that may be beneficial to your hair’s health is Kaemferol, which has been considered a powerful anti-inflammatory compound and antioxidant. (Chen and Chen 2013) Furthermore, Kaemferol can be used to improve blood circulation and remove blood stasis (Yu et al., 2013), which may account for Saw Palmetto’s potential effects on promoting hair growth.

Apigenin, another flavonoid in Saw Palmetto is also known as a good anti-inflammatory and antioxidant agent (Karamese et al., 2016), so both these flavonoids may help with the treatment of folliculitis and reducing inflammation of the scalp.

Phytosterols in Saw Palmetto

The beta sitosterol in saw palmetto is similar to cholesterol in its chemical structure and may be one of the ingredients in the plant that help most in the treatment of hair loss. It is used as a prevention method and in the management of a multitude of illnesses, from cancer to allergies.

Saw Palmetto is a DHT Blocker

A study in 2002 used 5-alpha reductase inhibitors such as liposterolic extract from saw palmetto and beta-sitosterol to see whether they work in the treatment of Androgenetic alopecia. The results of the study showed a great response to the treatment as 60% of the patients showed improvements. The authors believe that the beta-sitosterols and the liposterolic extract from the saw palmetto may work in the treatment of androgenetic alopecia as a DHT blocker via the enzyme 5-alpha reductase.(Prager et al.,2002)

Another study hypothesized that targeting 5AR as well as inflammatory pathways may have positive effects in AGA and benign prostatic hyperplasia, both being treated with 5-alpha reductase inhibitors such as finasteride. After testing hair follicle dermal papilla cells and prostate cells in vitro by exposing them to stigmasterol and beta sitosterol the authors concluded that the naturally derived 5-alpha reductase inhibitors represent a good approach in the treatment of androgenetic alopecia and benign prostatic hyperplasia. (Chen et al.,2016)

There’s another study that confirms the results of using stigmasterol and beta sitosterol isolated from plants as anti-inflammatory compounds (Gomez et al.,1999). The study was performed on rats with induced ear edema by using a topical solution and measuring the effect it had on their skin. The inflammation was reduced depending on the amount used in the ear with authors concluding that beta sitosterols and stimasterols are good anti-inflammatory agents when applied topically in acute inflammation.

Saw Palmetto’s Fatty Acids

It has been hypothesized that the fatty acids in saw palmetto may also contribute in inhibiting 5-alpha reductase and studies have shown their efficacy in benign prostatic hyperplasia (Horacio et al.,2011), which may suggest their effect as DHT blockers. Saw Palmetto’s fatty acids that may have effects on the scalp are lauric acid and oleic acid.

A study in 2009(Abe et al.) concluded that the major constituents of Saw Palmetto Extract, lauric acid, oleic acid, mysritic acid and linoleic acid inhibit 5AR activity. These fatty acids may contribute to inhibiting DHT in the scalp when using topical saw palmetto extract or liposterolic supplements and may account for the similar effects saw palmetto has with finasteride.

Saw Palmetto seems like a promising treatment with few to no side effects. It is already available and can be used by anyone as a liposterolic extract in capsules, a liquid extract or can be consumed as tea. However, those who want to get the benefits of the plant’s fatty acids should know that they are not soluble in water and by consuming it as tea they might miss on some of its beneficial effects.

References and further reading

  1. Marks, Leonard S et al. Tissue effects of saw palmetto and finasteride: use of biopsy cores for in situ quantification of prostatic androgens, Urology , Volume 57 , Issue 5 , 999 – 1005
  2. Rossi A, Mari E, Scarno M, Garelli V, Maxia C, Scali E, Iorio A, Carlesimo M. Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):1167-73.
  3. Jun-Hui Choi, Dae-Won Kim, Se-Eun Park, Hyo-Jeong Lee, Ki-Man Kim, Kyung-Je Kim, Myung-Kon Kim, Sung-Jun Kim, Seung Kim, Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille, Journal of Bioscience and Bioengineering, Volume 120, Issue 2, August 2015, Pages 181-186, ISSN 1389-1723, (
  4. h Carelli, S., Hebda, D. M., Traversa, M. V., Messaggio, F., Giuliani, G., Marzani, B., Benedusi, A., Di Giulio, A. M. and Gorio, A. (2012), A specific combination of zeaxanthin, spermidine and rutin prevents apoptosis in human dermal papilla cells. Exp Dermatol, 21: 953–955. doi:10.1111/exd.12029
  5. Chen, A. Y., & Chen, Y. C. (2013). A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chemistry, 138(4), 2099–2107.
  6. Victoria García-Mediavilla, Irene Crespo, Pilar S. Collado, Alejandro Esteller, Sonia Sánchez-Campos, María J. Tuñón, Javier González-Gallego, The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells, European Journal of Pharmacology, Volume 557, Issues 2–3, 28 February 2007, Pages 221-229, ISSN 0014-2999,
  7. Murat Karamese, Huseyin Serkan Erol, Mevlut Albayrak, Gulname Findik Guvendi, Emsal Aydin, and Selina Aksak Karamese Anti-oxidant and anti-inflammatory effects of apigenin in a rat model of sepsis: an immunological, biochemical, and histopathological study Immunopharmacology And Immunotoxicology Vol. 38 , Iss. 3,2016
  8. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med. 2002 Apr;8(2):143-52. Erratum in: J Altern Complement Med. 2006 Mar;12(2):199.
  9. Chen, L., Wang, J., Mouser, G., Li, Y. C., and Marcovici, G. (2016) Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays. Phytother. Res., 30: 1016–1020. doi: 10.1002/ptr.5611.
  10. Gómez MA, Sáenz MT, García MD, Fernández MA., Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models. Z Naturforsch C. 1999 Nov;54(11):937-41.
  11. Priestap, H.A., Quirke, J.M.E., Houle, P. et al. Chem Nat Compd (2011) 47: 511. doi:10.1007/s10600-011-9983-4
  12. Masayuki Abe, Yoshihiko Ito, Luvsandorj Oyunzul, Tomomi Oki-Fujino, , Shizuo Yamada, Pharmacologically Relevant Receptor Binding Characteristics and 5α-Reductase Inhibitory Activity of Free Fatty Acids Contained in Saw Palmetto Extract – Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, School of Pharmaceutical Sciences, University of Shizuoka

Increase Scalp PGE2 (and Decrease PGD2): The Cure for Hair Loss?

The precise cause of male pattern baldness has been discussed and researched for decades. But only in recent years have we started to pinpoint preceisely what causes the vast majority of hair loss. And we’re getting close…

there is more PGD2 in the scalps of bald men than in the scalps of men with hair

There have been speculations that reducing scalp DHT may be the key to curing hair loss but recent discoveries show that ‘prostaglandin D2’ might be just as important, or perhaps more so.

A paper from 2012 (Garza et al.) made the connection between prostaglandin D2 (PDG2) and hair loss, concluding that PGD2 might be the real key to curing androgenic alopecia. However, new research shows that increasing PGE2 (another prostaglandin found in the scalp) might be just as important in curing baldness and maintaining healthy hair.

The paper states (Garza et al. 2012) that there is more PGD2 in the scalps of bald men than in the scalps of men with hair. Clearly there is a link, but is it a causal link?

To sum it up in plain English and simplify:

High scalp PGD2 = hair loss
High scalp PGE2 = hair growth

Does decreasing scalp PGD2 and increasing scalp PGE2 cause hair to regrow?

In order to decrease PGD2 researchers tested COX1/COX2 inhibitors that also inhibited the production of PGE2, which shows that inhibiting PGD2 isn’t enough for a complete treatment and a dual approach to increase PGE2 and decrease PGD2 should be more efficacious.

The beneficial effects of PGE2 can be seen in a series of research papers. For example, Malkinson et al. (1993) have shown that prostaglandins, especially topical applications of PGE2 make for good radio-protective agents.

After the administration of topical applications of PGE2 Malkinson’s team saw that the areas were protected from radiation but also that there was an enhanced post-radiation hair regrowth.

Another study has found that elevated PGE2 levels in mice helped with tissue regeneration and it may help with hair regeneration. (Zhang et al.2015)

Anyone up to date with the latest research sees the link between PGE2 and baldness so the logical question is, how do we increase PGE2 in the scalp?

Increasing PGE2

Synthetic PGE2 Powder

You can buy synthetic PGE2 powder that contains the most biologically active prostaglandin and it’s used by scientists in various experiments. There is no standardized medical protocol for applying PGE2 powder to the scalp but there are studies showing topical application of PGE2 for treating vitiligo (a skin condition characterized by patches of pale color) by using a gel with high skin permeation that contains PGE2. (Kapoor et al. 2008; Parsad et al.2002) Synthetic PGE2 has a potency of 0.25-100 ng/mL and can be bought online.


Latisse bimatropost

Bimatoprost, also known as Latisse, is an effective treatment for intraocular pressure and glaucoma in adults. Researchers have proposed this drug for hair loss treatment and early stage trials seem promising. The drug thickens and lengthens the eyelashing by increasing PGE2 and PGF2 so in theory, the treatment should have similar effects in the scalp.

the treatment had amazing effects: the hair follicles stayed in anagen significantly longer and in vivo showed one third more hair growth

A huge upside to this treatment is that there are almost no side effects and since it can be applied topically by the patient it is easy to use at home. There was recent clinical trial (late 2016) to develop this into a marketed hair loss treatment. (Allergan 2016)

Previous studies have shown that the drug can grow human hair in vitro and mouse hair in vivo and the treatment had amazing effects: the hair follicles stayed in anagen significantly longer and in vivo showed one third more hair growth with bimatoprost treatment. (Karzan et al. 2013)

The results of the clinical trials on humans have shown that Bimatoprost 1% and Bimatoprost 3% result in superior hair growth when comparing the results with Minoxidil 5% results but further research on more people needs to be completed to provide stronger support for these statements. In any case, this shows that Bimatoprost might be the next big hair loss treatment.

Ginger root

its potential to increase PGE2 has been shown in studies

Ginger is a herbaceous perennial plant, which is a common ingredient in Asian cuisine. Ginger root has been a traditional Asian remedy for hair loss, and even though its effects on the human scalp haven’t been properly researched its potential to increase PGE2 has been shown in studies. Research shows that the plant has an anti-inflammatory effect and increases PGE2 (Shivanad, 2005) (Joland 2004).

A research on the effects of powdered ginger on the PGE2 levels in the gastric mucus production, scientists used aspirin to inhibit PGE2 production in the gastric mucus but when ginger was administered, the aspirin failed to inhibit PGE2 production. Also, when only ginger root was administered the mucus showed elevated levels of PGE2. (Wang et al., 2011)

So we have some pretty reasonable evidence that ginger increases PGE2 and may therefore be a useful topical.


their hair had regrown after long term baldness

Sulfasalazine is an anti-inflammatory drug used for rheumatoid arthritis, colitis or Crohn’s disease. The drug is known to increase PGE2 (Wittenberg et al., 1991; Sharon et al., 1978; ) Several case reports of people taking sulfasalazine for one of the illnesses above noticed their hair had regrown after long term baldness.

An uncontrolled study of sulfasalazine in 39 patients with alopecia areata showed that sulfasalazine increased hair regrowth of more than 60% in 25.6% of the patients who participated in the study while 30.7% of the patients had a moderate response to the drug. (Rashidi and Mahd, 2008)

6 of them (6 of 22 patients) achieving complete hair regrowth

Another study that used sulfasalazine as a hair loss treatment was conducted on 26 patients during a period of 3 years and according to the results, the patients were grouped into 3 categories: no hair regrowth <10% terminal hair, partial hair regrowth 10%-90% terminal hair and complete hair regrowth 90-100% hair regrowth. Only 22 of the patients completed the treatment and 68.2% which accounted for 15 of 22 patients responded to therapy with 6 of them (6 of 22 patients) achieving complete hair regrowth and 40.9 of them partial hair regrowth. (Aghaei, 2008)Both studies concluded that sulfasalazine could be considered as an alternative treatment to hair loss and although its mechanism is not completely known it is very likely to be linked to PGE2.

Castor Oil

Organic castor oil

Castor oil is a vegetable oil that is obtained by pressing the seeds of the Ricinus communis plant. It’s used as traditional medicine for a number of ailments including baldness with self-reporting cases all over the internet showing its effects. The mechanism behind hair loss might be its ability to increase PGE2 as research has shown. Studies on pregnant rats have shown that feeding them castor oil increases PGE2 synthesis. (Gao et al., 1999) (Tunaru et al.,2012 ) Although it hasn’t been studied as an actual treatment castor oil has been used topically for years without any side effects so giving it a try wouldn’t do any harm.

References and further reading

  1. Malkinson FD, Geng L, Hanson WR. Prostaglandins protect against murine hair injury produced by ionizing radiation or doxorubicin. J Invest Dermatol. 1993 Jul;101(1 Suppl):135S-137S.
  2. Yongyou Zhang, Amar Desai, Sung Yeun Yang, Ki Beom Bae, Monika I. Antczak,Stephen P. Fink, Shruti Tiwari, Joseph E. Willis, Noelle S. Williams, Dawn M. Dawson,David Wald, Wei-Dong Chen, Zhenghe Wang, Lakshmi Kasturi, Gretchen A. Larusch,Lucy He, Fabio Cominelli, Luca Di Martino, Zora Djuric, Ginger L. Milne, Mark Chance, Juan Sanabria, Chris Dealwis, Debra Mikkola, Jacinth Naidoo, Shuguang Wei, Hsin-Hsiung Tai, Stanton L. Gerson, Joseph M. Ready, Bruce Posner, James K. V. Willson,Sanford D. Markowitz. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration Science 12 Jun 2015: Vol. 348, Issue 6240, DOI: 10.1126/science.aaa2340
  3. Kapoor, R., Phiske, M.M. and Jerajani, H.R. (2009), Evaluation of safety and efficacy of topical prostaglandin E2 in treatment of vitiligo. British Journal of Dermatology, 160: 861–863. doi:10.1111/j.1365-2133.2008.08923.x
  4. Khidhir, K. G., Woodward, D. F., Farjo, N. P., Farjo, B. K., Tang, E. S., Wang, J. W., … Randall, V. A. (2013). The prostamide-related glaucoma therapy, bimatoprost, offers a novel approach for treating scalp alopecias. The FASEB Journal, 27(2), 557–567.
  5. Shivanand D. Jolad, R. Clark Lantz, Guan Jie Chen, Robert B. Bates, Barbara N. Timmermann, Commercially processed dry ginger (Zingiber officinale): Composition and effects on LPS-stimulated PGE2 production, Phytochemistry, Volume 66, Issue 13, July 2005, Pages 1614-1635, ISSN 0031-9422,
  6. Jolad SD, Lantz RC, Solyom AM, Chen GJ, Bates RB, Timmermann BN. Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production.
    Phytochemistry. 2004 Jul;65(13):1937-54.
  7. Zhongzhi Wang, Junichi Hasegawa, Xinhui Wang, Akiko Matsuda, Takahiro Tokuda, Norimasa Miura and Tatsuo Watanabe Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats Yonago Acta medica 2011;54:1119
  8. Wittenberg HR, Kleemeyer K, Peskar BM, Peskar BA. [Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue]. Wien Klin Wochenschr. 1991;103(2):34-9. German.
  9. Sharon P, Ligumsky M, Rachmilewitz D, Zor U. Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine. Gastroenterology. 1978 Oct;75(4):638-40.
  10. Ashidi, T. and Mahd, A. A. (2008), Treatment of persistent alopecia areata with sulfasalazine. International Journal of Dermatology, 47: 850–852. doi:10.1111/j.1365-4632.2008.03700.x
  11. Aghaei S. An uncontrolled, open label study of sulfasalazine in severe alopecia areata. Indian J Dermatol Venereol Leprol [serial online] 2008 [cited 2017 Jan 11];74:611-3. Available from:
  12. Tunaru S, Althoff TF, Nüsing RM, Diener M, Offermanns S.Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9179-84. doi: 10.1073/pnas.1201627109.

Stem Cell Therapy for Hair Loss

The advances in understanding the complex mechanisms behind hair loss as well as improvements in stem cell therapy may completely change the way we approach the treatment of hair loss.

Stem cells are undifferentiated cells that have the potential to become different cell types as well as regenerate tissues and organs. This unique characteristic makes them perfect tools in the treatment of degenerative diseases.

Hair follicle stem cells are among the most potent forms of stem cells in the human body

There are two types of stem cells: embryonic stem cells and adult stem cells. While embryonic stem cells can differentiate into any type of cells, the adult stem cells have some limitations.

The regeneration period of stem cells also depends on the type of organ stem cell. For example, in hair follicles and bone marrow, the stem cells divide frequently to replenish the damaged cells continuously throughout life. (Chen and Chong, 2012)

Hair Stem Cells

stem cells are activated by molecules released from intra-dermal fat tissue, hormones, neural activity, immune function and even the aging process

The hair follicle is a mini organ that supports various biological functions of the human body such as protecting from the cold and from injury as well as immunologic and sensory functions. Hair follicle stem cells are among the most potent forms of stem cells in the human body. Their diverse set of functions and ease of reproduction have made them one of the most popular choices when it comes to stem cell interventions such as the engineering of tissue for organ replacement or regenerative medicine. Their vast qualities and flexibility also explains why so much research and scientific literature has been devoted to studying their full potential.

Hair follicle stem cells are kicked into action by a number of signals that come from their micro-environment but also from far larger bodily functions. Stem cells that are located in hair follicles interact with signals from the dermal papilla. While outside the follicle, stem cells are activated by molecules released from intra-dermal fat tissue, hormones, neural activity, immune function and even the aging process. Even external factors like the changing of seasons can interact with the activity of hair follicle stem cells. Due to their regrnerative properties and adaptiveness to various environments hair cells were chosen to become the model for stem cell biology (Chen and Chong, 2012).

Hair Cloning

Shiseido and Replicel have combined forces in order to develop one of the most advanced treatments for hair loss

The history of stem cell therapy for hair growth started with a company called Intercytex. Researchers tried to clone new hair follicles that were grown from the stem cells harvested from the back of the head. Their Phase 2 trials showed promising results in two thirds of their patients as they grew new hair after the stem cell treatment. Unfortunately, the company went out of business after the Phase 3 trials didn’t go as expected.

In the last 3 years, more and more companies have announced their clinical trials for stem cell hair loss treatments.

The major research teams developing treatments using stem cells are Replicel-Shiseido and Riken. The other new stem cell treatment that is already available is the HASCI method developed by Dr. Gho.

Shiseido and Replicel



Shiseido and Replicel have combined forces in order to develop one of the most advanced treatments for hair loss. They propose the use of dermal sheath cup cells that have been isolated from the hair follicle. Replicel’s hair growth treatment, known as RCH-01 works by re-injecting a person’s own hair follicle cells into parts of the scalp. The cells are removed from healthy hair follicles and cultured into a growth medium that replicates them. After the culturing process is done the cells are injected into the scalp.

Shiseido is a Japanese company that obtained the rights to develop RCH-01. Moreover, the company is working on a new regenerative technique that uses iPS cells. Currently, Shiseido is undergoing clinical trials for Replicel’s RCH-01 in Japan at Tokyo Medical University Hospital and Toho University Ohasi Medical Center under the guidance of Dr. Tsuboi and Niiyama and has an estimated market release in 2018. The product will be manufactured by the Shiseido facility in Kobe.

Tsujji-Riken Organ Technologies

Tsuji-Riken Organ Technologies research led by Dr. Takashi Tsuji is also creating and researching a cure for hair loss that involves stem cells. The researchers are known for their successes in regenerating other body parts such as teeth, glands, and hair follicles by using a process called the Primordium method.

Primordium Method

The researchers remove a small patch of skin and hair follicles form the patient’s scalp and isolate and extract the follicles to be cultivated. After they have been cultivated and multiplied the cells are processed and turned into follicles using the Primordium method and injected into the scalp.

The method requires bioengineering that would allow them to accurately transport and inject the cells into the scalp so the company is working with Kyocera in order to produce the equipment needed for this procedure.

The HASCI method

The HASCI method is already available.

The Hair Science Institute researches advanced hair transplantation and multiplication methods in its various clinics in Amsterdam, London, Maastricht, Jakarta and Cap d’Antibes. The method was developed by the research team lead by Coen Gho and they are focusing on continually improving its efficiency.

The method does not remove the entire hair follicle, but only a portion of it along with the stem cells it contains. Studies performed by Dr. Gho hve shown that this is enough to produce new hair in both areas (donor and receptor).(Gho and Norman, 2015). This means that the partial follicle left in the donor area will produce growth whereas in traditional hair transplantation methods the donor area couldn’t be used again. The stem cells are then placed in a medium that will stimulate further growth. (Gho and Neuman, 2014)

The method also works for patients who experienced hair loss after burning accidents (Gho and Neuman, 2011) and allows for a natural look and quick recovery (5-7 days). The full result can be seen after 9 months, when the hair growth cycle is completed.

Due to the diverse techniques that are being developed, there isn’t a single approach to stem cell therapy, as each researcher is in the process of developing not only their own treatment approach but also their own tools. Stem cell therapy is superior to other types of hair loss therapies due to its minimally invasive approach as well as little to no side effects. Due to being a non-surgical approach with minimal to no scarring, stem cell treatment may becomne the favoured approach to hair restoration. Many of the traditional forms of hair loss therapies such as DHT blockers not only have side effects but also have to be used daily and indefinitely. Stem Cell Therapy also improves the quality and texture of hair in long term and effects are noticed much faster than with other types of hair loss treatments.

Plant Stem Cells

Plants also have stem cells that behave very much like hair fibre stem cells, with impulses from their surrounding microenvironment dictating their activity and function. Unlike human stem cells though, plant stem cells can be totipotent, which means they have the power to regenerate an entire plant not just an element or part of a plant.

Stem cells from plants can also be used to improve human hair, particularly due to the properties that keep fruit fresh for long periods of time. In fact, the most important, research based approach to improving the condition of hair through plant derived stem cells has been achieved with the help of the Uttwiler Spätlauber apple tree. Malus Domestica is a cosmetic ingredient that is derived from stem cells harvested from the Swiss apple tree.

The stem cells extracted from this hearty tree that have been combined with human derived stem cells have resulted in a far more resistant stem cell product, even when subjected to extremely harsh conditions and UV light (Schmidt et al). The apple derived extract didn’t just offer protection from UV light and growth maintenance to human stem cells but also delayed cell deterioration and postponed the hair follicle’s death.

The research done on plant stem cells is still in its infancy; however, it shows promise as an important addition to classic stem cell treatment for hair loss and provides important benefits that will make any future products more efficient.


    Chen, C.-C., & Chuong, C. M. (2012). Multi-layered environmental regulation on the homeostasis of stem cells: The saga of hair growth and alopecia. Journal of Dermatological Science, 66(1), 3–11.
  • Mistriotis, P., & Andreadis, S. T. (2013). Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine.Tissue Engineering. Part B, Reviews, 19(4), 265–278.

    RCH-01 – Hair Regeneration

  • Gho C.G, Neumann H.A.M,  Advances in Hair Transplantation: Longitudinal Partial Follicular Unit Transplantation, Ioannides D, Tosti A (eds): Alopecias – Practical Evaluation and Management. Curr Probl Dermatol. Basel, Karger, 2015, vol 47, pp 150-157 (DOI:10.1159/000369416)
  • Gho, C. G., & Neumann, H. A. M. (2013). The Influence of Preservation Solution on the Viability of Grafts in Hair Transplantation Surgery. Plastic and Reconstructive Surgery Global Open, 1(9), e90.
  • Gho, C. G., & Neumann, H. A. M. (2011) Improved hair restoration method for burns, Burns , Volume 37 , Issue 3 , 427 – 433